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Carlos Encinas Dominguez
Researcher at University of Arizona
Publications - 9
Citations - 2086
Carlos Encinas Dominguez is an academic researcher from University of Arizona. The author has contributed to research in topics: Calcitriol receptor & Retinoid X receptor. The author has an hindex of 6, co-authored 9 publications receiving 2000 citations.
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Journal ArticleDOI
The nuclear vitamin D receptor: biological and molecular regulatory properties revealed.
Mark R. Haussler,G. K. Whitfield,Carol A. Haussler,J. C. Hsieh,Paul Thompson,S. H. Selznick,Carlos Encinas Dominguez,Peter W. Jurutka +7 more
TL;DR: The scope of this review will be limited to highlighting the actions of 1,25(OH)2D3 mediated by nuclear VDR and discussing new developments in the structure/function analysis of the receptor, including the phenotype of VDR knockout mice and the biochemical classification of patients with point mutations in the receptor.
Journal ArticleDOI
Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene.
G. Kerr Whitfield,L. S. Remus,Peter W. Jurutka,Heike Zitzer,Anish K. Oza,Hope Dang,Carol A. Haussler,Michael A. Galligan,Michelle L. Thatcher,Carlos Encinas Dominguez,Mark R. Haussler +10 more
TL;DR: Functional relevance for both the F/f and L/S common polymorphisms in hVDR is demonstrated, and novel evidence for a third genetic variable impacting receptor potency is provided.
Journal ArticleDOI
Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements
Paul Thompson,Peter W. Jurutka,G. Kerr Whitfield,Sandy M Myskowski,Kristina R. Eichhorst,Carlos Encinas Dominguez,Carol A. Haussler,Mark R. Haussler +7 more
TL;DR: Data suggest that 1,25D(3)-dependent, VDR-mediated induction of CYP3A4 may constitute a chemoprotective mechanism for detoxification of enteric xenobiotics and carcinogens.
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Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth
G. Kerr Whitfield,Hope Dang,Samuel F. Schluter,Ralph M. Bernstein,Tara Francis Bunag,Lori A. Manzon,Grace Hsieh,Carlos Encinas Dominguez,John H. Youson,Mark R. Haussler,John J. Marchalonis +10 more
TL;DR: It is proposed that, in this evolutionarily ancient vertebrate, VDR may function in part, like pregnane X receptors and constitutive androstane receptors, to induce P450 enzymes for xenobiotic detoxification.
Journal ArticleDOI
Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.
Peter W. Jurutka,Paul Thompson,Paul Thompson,G. Kerr Whitfield,Kristina R. Eichhorst,Neal Hall,Carlos Encinas Dominguez,Jui Cheng Hsieh,Carol A. Haussler,Mark R. Haussler +9 more
TL;DR: It is proposed that VDR is a bifunctional regulator, with the 1,25(OH)2D3‐liganded conformation facilitating high affinity endocrine actions, and the LCA‐liganding configuration mediating local, lower affinity cellular detoxification by upregulation of CYP3A4 in the colon.