A number of drugs are capable of changing bodyweight as an adverse effect of their therapeutic action. Bodyweight gain is more of a problem than bodyweight loss. As bodyweight gain during drug treatment for any kind of disease may be the reflection of improvement of the disease itself, we will try to separate these effects from those due to drug-induced alterations of the mechanisms regulating bodyweight. Bodyweight gain may jeopardise patient compliance to the prescribed regimen and it may pose health risks.

Bodyweight change as an adverse effect of drug treatment : Mechanisms and management

Menstrual bleeding patterns in untreated women

Microdose intravaginal levonorgestrel contraception: A multicentre clinical trial

Study selection Randomised controlled trials that evaluated non-surgical interventions for non-pregnant women with irregular or abnormal cyclic uterine bleeding for three months or more were eligible for inclusion. Studies of women with polycystic ovarian syndrome were included with studies of irregular bleeding as long as the patient baseline and outcome data included information regarding cycle regularity. Studies of women with abnormal uterine bleeding caused by coagulation defects, systemic disease, structural abnormalities, cancer, medication side-effects or infertility (with a primary treatment goal of conception) were excluded. Outcomes of interest included bleeding profile, quality of life, pain, sexual function and patient satisfaction with treatment outcomes. For evidence of harms, observational studies with at least 1,600 participants/records were included.

Primary care management of abnormal uterine bleeding

https://www.obgyn.theclinics.com/article/S0889-8545(05)70171-6/pdf

INJECTABLE CONTRACEPTION: New and Existing Options

A multicentred phase III comparative study of two hormonal contraceptive preparations given once-a-month by intramuscular injection: II. The comparison of bleeding patterns

G. Perez-Palacios

Papers

A multicentred phase III comparative study of two hormonal contraceptive preparations given once-a-month by intramuscular injection: II. The comparison of bleeding patterns