Showing papers in "Contraception in 1989"

TL;DR: The consensus of the group was that the maximum birth spacing effect of breastfeeding is achieved when a mother "fully" or nearly fully breastfeeds and remains amenorrheic.

TL;DR: It is reported that gossypol inactivates human immunodeficiency virus (HIV) in an in vitro system and observations suggest that gOSSypol could be used as a vaginal spermicidal/virucidal agent.

TL;DR: Exposure to mineral oil, a common component of hand lotions and other lubricants used during sexual intercourse, caused approximately 90% decrease in the strength of the condoms, as measured by their burst volumes in the standard ISO Air Burst Test.

TL;DR: The result of the study suggests that RU 486, when administered in the postovulatory phase, directly affects the capillary vessels of the endometrium.

TL;DR: The higher EE levels with EE/GSD as compared to EE/DG seem to be due to a retardation of the inactivation and elimination of EE caused by the progestogen component, and the rise in the EE levels during each cycle seems to be a reduction in the oxidative metabolism by EE itself.

TL;DR: The observations from the present study based on 36 months of experience with different intrauterine devices do not indicate the need to replace CuT 200, the device currently in use in the National Programme.

TL;DR: Effects of oral contraception on cancers of the female breast and reproductive tract are critically reviewed from human studies reported since 1980 and there is evidence suggesting an elevated risk which approaches a 2-fold increase at 10 years of use.

TL;DR: It is suggested that IUD and high-dose ethinylestradiol are more efficacious forms of post-coital contraception than danazol or combined contraceptives.

TL;DR: No significant prolongation of the cycle lengths was seen when L-NOG was taken during the follicular phase, and only minor effects in the endometrium were observed during treatment.

TL;DR: Findings show that RU 486 prevented ovulation by diminishing pituitary gonadotropin secretion, rather than by direct effects on ovarian folliculogenesis, and induced amenorrhea by inhibiting estrogen-induced endometrial proliferation.

TL;DR: The analysis suggests how the life-table analysis of discontinuation reasons underestimates the true incidence of vaginal bleeding irregularities in a clinical trial.

TL;DR: Light and scanning electron microscopy showed that both in vivo and in vitro treatment with the drug causes profound morphological changes in spermatozoa such as decapitation of the spermatozosal head and alteration in the shape of the cytoplasmic droplet in the tail.

TL;DR: Differences between the AUC-EE of pairs from the same manufacturer were not significantly different, indicating that 50ug of mestranol was equivalent to 35ug ethinyl estradiol with respect to this pharmacokinetic parameter.

TL;DR: Weight gain of unsupplemented infants, the most important of the several criteria used to assess breast-feeding performance, was similar for the two contraceptive groups.

TL;DR: This is the first evidence that a single intratesticular injection of glycerol results in long-term suppression of spermatogenesis in primates, without altering testicular steroidogenesis and serum hormone levels.

TL;DR: This study confirmed the effectiveness of mifepristone and prostaglandin for the induction of early abortion but suggests that more research should be carried out to determine the lowest effective doses of both drugs.

TL;DR: Results indicate that breastfeeding women inserted with a TCu-380A are more likely than non-breastfeeding women to have a smooth, pain-free insertion, few postinsertion bleeding and pain problems, and a high rate of continuation of IUD use.

TL;DR: The results of a prospective longitudinal controlled study comparing the coagulation effects of a standard low-dose combined oral contraceptive, a desogestrel-containing pill and a triphasic preparation after one year's treatment in ethnic Chinese women is presented.

TL;DR: The findings suggest that the morphological changes observed are due to alterations in the glycoproteins associated with the lipid bilayer of plasma membrane of spermatozoa.

TL;DR: Potent in vitro spermicidal activity of parabens against human spermatozoa was demonstrated in this study and less toxicity and side effects were expected for the development ofParabens as vaginal contraceptive agents.

TL;DR: The pattern and amount of blood loss following induction of therapeutic abortion using mifepristone (RU 486) and a prostaglandin E analogue (gemeprost) was studied in 222 women of less than 63 days amenorrhoea as discussed by the authors.

TL;DR: The high rate of acceptability and efficacy of transdermal testosterone in male hypogonadism has been demonstrated and is expected to make a significant impact on the quality of patient care both in men and in women.

TL;DR: The results indicate that the new testosterone ester has highly favourable pharmacokinetic properties and may prove to be the androgen of choice for supplementation therapy in contraceptive regimens.

TL;DR: The overall percentage use of contraceptive methods, especially the reliable ones, was found to be high (95%).

TL;DR: Competitive studies indicated that gestodene like other synthetic progestagens also displays some affinity for androgen and glucocorticoid receptors but no measurable affinity for the estrogen receptor, and remarkable is the high binding affinity of gestodenes to the binding sites of the mineraloc Corticoid receptor of rat kidney with a RBA value of 350% compared to aldosterone.

TL;DR: Gestodene plasma levels indicate that gestodene is completely absorbed and systemically available at all doses investigated, andabsolute bioavailabilities were calculated as 87.5 ± 17.5 % (25 μg), 99.3 ± 10.9 % (75 μg ) and 110.8 ± 17

TL;DR: There were highly significant differences between the IUDs at the endometrial level as displayed by morphometry, however, the difference between bleeders and non-bleeders was not significant in any of the three types of Iuds.

TL;DR: Although the protection for invasive cancer appeared to be greater at older ages and in multiparous women, the relative risks were not significantly heterogeneous in various strata of parity, number of sexual partners, oral contraceptive use and history of Pap smears.

TL;DR: Differences in the responses of ostensibly closely related proteins of hepatic origin such as SHBG and CP to the oral contraceptives demonstrate that neither can be extrapolated to other pharmacodynamic responses.

TL;DR: Treatment with Antide produced profound long-term inhibition of tonic gonadotropin levels, yet hyper-responsiveness to exogenous GnRH administration was maintained throughout.