A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.

Publisher Summary This chapter provides an overview of the morphology of central monoamine neurons and the function of central monoamine neurons. The Nigro–Neostriatal neurons perform both the motor and mental functions. Their degeneration causes hypokinesia and rigidity while overstimulation of neostriatal dopamine (DA) receptors causes stereotyped behavior. The tubro-infundibular DA neurons probably act by way of inhibiting the release of luteinizing hormone releasing factor (LHRF) from the median eminence. The central noradrenaline (NA) neurons perform various functions, such as function in wakefulness, emotion, behavior, neuroendocrine function, and function in reflex activity. The central 5-hydroxytryptamine (5-HT) neurons contribute to the function in mood, wakefulness, thought process, behavior, neuroendocrine function, and function in reflex activity. The NA neurons probably are essential for conditioned processes as are the DA neurons while a destruction of the 5-HT neurons results in insomnia. Increased NA receptor activity results in aggression. The descending bulbospinal 5-HT neurons participate in the control of autonomic and somatic reflex activity, especially in the lumbosacral part.

G. Vassent

Papers

Blockade of superovulation in the immature rat by increased brain serotonin.