Showing papers by "Gabriel Rubio published in 2022"
TL;DR: LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs, according to the main aim of the present study.
Abstract: Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.
3 citations
TL;DR: In this paper , the gray (GM) and white matter (WM) volumes in male participants with AUD without FHA compared to healthy control males (HC) with FHA were investigated.
1 citations
TL;DR: The VCR appears to distinguish between patients with early and stable sobriety, and confirmatory factor analysis suggests the presence of a single factor, with relatively acceptable values of goodness of fit and factor loadings.
Abstract: Abstract Recovery from alcohol use disorder involves achieving certain resources for positive lifestyle changes, well-being, and long-term abstinence. The present study aims to translate and validate the Assessment Capital Recovery (ARC) in a Spanish clinical sample of individuals with alcohol use disorder, in abstinence. The participants were 184 patients who attended outpatient treatments. They were evaluated with the adapted version of the ARC (Spanish abbreviation: “Valoración del Capital de Recuperación, VCR”) and by WHOQOL-BREF (quality of life scale), in one session. Statistical analysis included the calculation of reliability, convergent validity (relationship with WHOQOL-BREF), specificity and sensitivity, as well as validity based on internal structure (confirmatory factor analysis). VCR scores show appropriate values for reliability (α = .90), and a low convergent validity with WHOQOL-BREF (Rho = .33–.53). The VCR appears to distinguish between patients with early and stable sobriety (χ2 = 20.55, p < .01). The ROC curve indicates significant discrimination values (p < .05) for stable recovery (5 years of abstinence) and sensitivity of 85.2% and specificity of 71.2%. Further, confirmatory factor analysis suggests the presence of a single factor, with relatively acceptable values of goodness of fit and factor loadings. We used ULS parameter estimation to study VCR properties, an appropriate tool for assessing recovery in clinical populations of individuals with alcohol use disorder in abstinence.
1 citations
TL;DR: Atención primaria, hospitalaria, and servicios sociales, as a part of a conjunto sanitarias integradas, existiendo diferencias significativas entre cada una de ellas, según se refleja en sus particulares Planes de Salud as discussed by the authors .
Abstract: La atención en Salud Mental ha sufrido una radical transformación a lo largo de la historia, tanto desde el punto de vista asistencial como de la consideración de la enfermedad, siendo el punto de inflexión definitivo el momento en que la cobertura de las enfermedades mentales se integró dentro del Sistema de Salud. Desde entonces, la organización de la Salud Mental ha evolucionado atendiendo a las diferentes necesidades de la sociedad, hasta llegar actualmente a las organizaciones sanitarias integradas, donde operan de forma conjunta la Atención Primaria, la hospitalaria y los servicios sociales, tanto desde una perspectiva asistencial como de gestión. Además, hay que tener presente que España cuenta en la actualidad con un sistema sanitario de cobertura universal que está transferido a las Comunidades Autónomas, existiendo diferencias significativas entre cada una de ellas, según se refleja en sus particulares Planes de Salud.
La metodología utilizada se basa en las técnicas de investigación histórica centrado el análisis en la evolución histórica de la salud mental y cómo se ha abordado desde las Comunidades Autónomas que son objeto de estudio dicha patología.
Los desequilibrios territoriales y de asignación de recursos se incrementan en periodos de crisis. En el presente trabajo se analiza este tipo de atención en dos comunidades autónomas, el País Vasco y Cataluña, que aun siendo ambas de naturaleza avanzada, presentan diferencias significativas.
TL;DR: In this paper , the neuroelectrical oscillations in people with alcohol use disorder (AUD) with longer and shorter abstinence time in comparison with healthy individuals were studied and the obtained results reflect that abstinence maintenance for six or more months appears to produce an important oscillatory brain functioning normalization.