Gabriela Camporeale

TL;DR: In this paper, the basic principles of liquid-liquid phase separation are discussed in connection with several examples of VFs and a view which integrates viral replication mechanisms with the biochemistry underlying liquid-like organelles is proposed.

TL;DR: A functional redox activity is proposed that adds to the previously discovered chaperone activity of E7 and supports the picture of a moonlighting pathological role of this paradigmatic viral oncoprotein.

TL;DR: A unique protein without homologs, structure or mechanistic information may switch between monomers and oligomers in conditions compatible with the cellular environment and be potentially modulated by crowding or compartmentalization.

TL;DR: Evolution pinpoints conformational hot spots that could have not been identified by direct experimental methods for analyzing or perturbing the equilibrium of an intrinsically disordered protein ensemble, and uncovers the existence of local structural elements that oppose canonical folding.

TL;DR: This work dissected the molecular mechanisms by which E7 oncoprotein can sense and manage the potentially harmful oxidative environment of the papillomavirus-infected cell and identified a couple of low pKa nucleophilic cysteines that can form a disulfide bridge upon the exposure to ROS and regulate the cytoplasm to nucleus transport.