G
Gabrielle Heilek
Researcher at Hoffmann-La Roche
Publications - 49
Citations - 1325
Gabrielle Heilek is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Reverse transcriptase & Reverse-transcriptase inhibitor. The author has an hindex of 18, co-authored 47 publications receiving 1262 citations.
Papers
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Journal ArticleDOI
Optimal Detection of Fetal Chromosomal Abnormalities by Massively Parallel DNA Sequencing of Cell-Free Fetal DNA from Maternal Blood
Amy J. Sehnert,Brian Kent Rhees,David Comstock,Eileen de Feo,Gabrielle Heilek,John P. Burke,Richard P. Rava +6 more
TL;DR: Massively parallel sequencing is capable of detecting multiple fetal chromosomal abnormalities from maternal plasma when an optimized algorithm is used.
Patent
Sequencing methods and compositions for prenatal diagnoses
TL;DR: In this paper, the authors proposed a massively parallel sequencing method for determining aneuploidy and fetal fraction in maternal samples comprising fetal and maternal cfDNA by massive parallel sequencing.
Patent
Methods for determining fraction of fetal nucleic acid in maternal samples
Richard P. Rava,Yue-Jen Chuu,Manjula Chinnappa,David A. Comstock,Gabrielle Heilek,Michael Hunkapiller +5 more
TL;DR: In this paper, the fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy in a maternal sample comprising a mixture of fetal and maternal nucleic acid.
Journal ArticleDOI
Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.
Zachary Kevin Sweeney,Seth F. Harris,Nidhi Arora,Hassan Javanbakht,Yu Li,Jennifer Fretland,James Edward Paul Davidson,J. Roland Billedeau,Shelley K. Gleason,Donald Roy Hirschfeld,Joshua Kennedy-Smith,Taraneh Mirzadegan,Ralf Roetz,Mark D. Smith,Sarah Sperry,Judy M. Suh,Jeffrey Wu,Stan Tsing,Armando G. Villaseñor,Amber Paul,Guoping Su,Gabrielle Heilek,Julie Q. Hang,Amy S. Zhou,Jesper A. Jernelius,Fang‐Jie Zhang,Klaus Klumpp +26 more
TL;DR: Structural-based optimization of diaryl ether inhibitors led to the discovery of a new series of pyrazolo[3,4-c]pyridazine NNRTIs that bind the reverse transcriptase enzyme of human immunodeficiency virus-1 (HIV-RT) in an expanded volume relative to most other inhibitors in this class.
Patent
Simultaneous determination of aneuploidy and fetal fraction
TL;DR: In this paper, the authors present compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form a pregnant female.