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Brian Kent Rhees
Researcher at Hoffmann-La Roche
Publications - 44
Citations - 2210
Brian Kent Rhees is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Odds ratio & Coronary artery disease. The author has an hindex of 18, co-authored 44 publications receiving 2080 citations. Previous affiliations of Brian Kent Rhees include Vanderbilt University & North Carolina State University.
Papers
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Journal ArticleDOI
Changes in circulating microRNA levels associated with prostate cancer
Richard J. Bryant,Traci Pawlowski,James W.F. Catto,G Marsden,Robert L. Vessella,Brian Kent Rhees,C. Kuslich,Tapio Visakorpi,Freddie C. Hamdy +8 more
TL;DR: Observations suggest that changes in miR concentration in prostate cancer patients may be identified by analysing various body fluids, and circulating miRs may be used to diagnose and stage prostate cancer.
Journal ArticleDOI
Optimal Detection of Fetal Chromosomal Abnormalities by Massively Parallel DNA Sequencing of Cell-Free Fetal DNA from Maternal Blood
Amy J. Sehnert,Brian Kent Rhees,David Comstock,Eileen de Feo,Gabrielle Heilek,John P. Burke,Richard P. Rava +6 more
TL;DR: Massively parallel sequencing is capable of detecting multiple fetal chromosomal abnormalities from maternal plasma when an optimized algorithm is used.
Journal ArticleDOI
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.
Inga Reynisdottir,Gudmar Thorleifsson,Rafn Benediktsson,Gunnar Sigurdsson,Valur Emilsson,Anna S. Einarsdóttir,Eyrun Edda Hjorleifsdottir,Gudbjorg Orlygsdottir,Gudrun Thora Bjornsdottir,Jona Saemundsdottir,Skarphedinn Halldorsson,Soffia M. Hrafnkelsdottir,Steinunn Bjorg Sigurjonsdottir,Svana Steinsdottir,Mitchell Martin,Jarema Peter Kochan,Brian Kent Rhees,Struan F.A. Grant,Michael L. Frigge,Augustine Kong,Vilmundur Gudnason,Kari Stefansson,Jeffrey R. Gulcher +22 more
TL;DR: In this paper, a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic population was conducted and a nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.
Journal ArticleDOI
Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information
Matthew E. Mealiffe,Renee Stokowski,Brian Kent Rhees,Ross L. Prentice,Mary Pettinger,David A. Hinds +5 more
TL;DR: Combining validated common genetic risk factors with clinical risk factors resulted in modest improvement in classification of breast cancer risks in white non-Hispanic postmenopausal women.
Patent
Sequencing methods and compositions for prenatal diagnoses
TL;DR: In this paper, the authors proposed a massively parallel sequencing method for determining aneuploidy and fetal fraction in maternal samples comprising fetal and maternal cfDNA by massive parallel sequencing.