G
Gabrielle S. Le Provost
Researcher at Centre national de la recherche scientifique
Publications - 2
Citations - 147
Gabrielle S. Le Provost is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Lysyl oxidase & Gene silencing. The author has an hindex of 2, co-authored 2 publications receiving 125 citations.
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Journal ArticleDOI
The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Floriane Pez,Frédéric Dayan,Jérôme Durivault,Bastien Kaniewski,Géraldine Aimond,Gabrielle S. Le Provost,Blandine Deux,Philippe Clézardin,Pascal Sommer,Jacques Pouysségur,Caroline Reynaud +10 more
TL;DR: Mechanistic investigations revealed that LOX activated the PI3K (phosphoinositide 3-kinase)-Akt signaling pathway, thereby upregulating HIF-1α protein synthesis in a manner requiring LOX-mediated hydrogen peroxide production, suggesting that Hif-1/LOX mutual regulation is a pivotal mechanism in the adaptation of tumor cells to hypoxia.
Journal ArticleDOI
Lysyl oxidase silencing impairs keratinocyte differentiation in a reconstructed-epidermis model.
Gabrielle S. Le Provost,Romain Debret,Valerie Cenizo,Géraldine Aimond,Floriane Pez,Bastien Kaniewski,Valerie Andre,Pascal Sommer +7 more
TL;DR: Lysyl Oxidase silencing impairs keratinocyte differentiation in a reconstructed‐epidermis model and needs further investigation to determine the mechanism behind this effect.