G
Gamze Bora-Tatar
Researcher at Hacettepe University
Publications - 6
Citations - 205
Gamze Bora-Tatar is an academic researcher from Hacettepe University. The author has contributed to research in topics: Spinal muscular atrophy & SMA*. The author has an hindex of 4, co-authored 6 publications receiving 174 citations.
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Journal ArticleDOI
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Gamze Bora-Tatar,Didem Dayangac-Erden,Ayhan S. Demir,Sevim Dalkara,Kemal Yelekçi,Hayat Erdem-Yurter +5 more
TL;DR: 33 carboxylic acid derivatives were tested and caffeic acid derivatives such as chlorogenic acid and curcumin were found to be highly potent compared to sodium butyrate, which is a well-known HDAC inhibitor.
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Investigations of Curcumin and Resveratrol on Neurite Outgrowth: Perspectives on Spinal Muscular Atrophy
TL;DR: Although curcumin and resveratrol failed to restore the neurite outgrowth defects, the SMN protein was found to be necessary for the neurITE-promoting activity ofCurcumin in neuron-like PC12 cells.
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Carboxylic acid derivatives of histone deacetylase inhibitors induce full length SMN2 transcripts: a promising target for spinal muscular atrophy therapeutics.
TL;DR: Caffeic acid and curcumin were more efficient than chlorogenic acid and increased full-length SMN2 mRNA levels and suggested that carboxylic acid derivatives including phenolic structure and symmetry could be a good candidate for SMA treatment.
Journal ArticleDOI
Spinal muscular atrophy type III: Molecular genetic characterization of Turkish patients.
Gamze Bora-Tatar,Ayşe Yeşbek-Kaymaz,Can Ebru Bekircan-Kurt,Sevim Erdem-Ozdamar,Hayat Erdem-Yurter +4 more
TL;DR: Molecular genetic characteristics of 24 Turkish type III SMA patients determined that male patients who were born in consanguineous families were predominant in this cohort and these patients mostly carry the homozygous loss of SMN1 exon 7 and 8 and four copies ofSMN2 gene without NAIP deletions.
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Effects of flavonoid quercetin on survival of motor neuron gene expression
TL;DR: Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level, which is an important modifier of SMA.