H
Hayat Erdem-Yurter
Researcher at Hacettepe University
Publications - 19
Citations - 372
Hayat Erdem-Yurter is an academic researcher from Hacettepe University. The author has contributed to research in topics: Spinal muscular atrophy & SMA*. The author has an hindex of 8, co-authored 17 publications receiving 304 citations.
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Journal ArticleDOI
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Gamze Bora-Tatar,Didem Dayangac-Erden,Ayhan S. Demir,Sevim Dalkara,Kemal Yelekçi,Hayat Erdem-Yurter +5 more
TL;DR: 33 carboxylic acid derivatives were tested and caffeic acid derivatives such as chlorogenic acid and curcumin were found to be highly potent compared to sodium butyrate, which is a well-known HDAC inhibitor.
Journal ArticleDOI
Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients.
TL;DR: VDR gene TaqI polymorphism is associated with familial psoriasis in the Turkish population and it is demonstrated that VDR gene polymorphisms may play a role in partial resistance to calcipotriol therapy.
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Histone deacetylase inhibition activity and molecular docking of (e )-resveratrol: its therapeutic potential in spinal muscular atrophy.
Didem Dayangac-Erden,Gamze Bora,Peruze Ayhan,Çetin Kocaefe,Sevim Dalkara,Kemal Yelekçi,Ayhan S. Demir,Hayat Erdem-Yurter +7 more
TL;DR: It is found that (E )‐resveratrol, one of the polyphenolic compounds, inhibited histone deacetylase activity in a concentration‐dependent manner and half‐maximum inhibition was observed at 650 μm.
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Investigations of Curcumin and Resveratrol on Neurite Outgrowth: Perspectives on Spinal Muscular Atrophy
TL;DR: Although curcumin and resveratrol failed to restore the neurite outgrowth defects, the SMN protein was found to be necessary for the neurITE-promoting activity ofCurcumin in neuron-like PC12 cells.
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Effects of Arm Cycling Exercise in Spinal Muscular Atrophy Type II Patients: A Pilot Study:
Gamze Bora,Şulenur Subaşı-Yıldız,Ayşe Yeşbek-Kaymaz,Numan Bulut,I. Alemdaroglu,Öznur Tunca-Yılmaz,Haluk Topaloglu,Aynur Ayşe Karaduman,Hayat Erdem-Yurter +8 more
TL;DR: It is demonstrated that the patients tolerated the exercise protocol and gained a benefit from arm cycling but benefits could not be associated with SMN2 copy number, SMN protein level, IGF1, or IGFBP3 levels.