G
Gang Wang
Researcher at Third Military Medical University
Publications - 20
Citations - 3421
Gang Wang is an academic researcher from Third Military Medical University. The author has contributed to research in topics: CD8 & T cell. The author has an hindex of 8, co-authored 18 publications receiving 1950 citations.
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Journal ArticleDOI
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19).
Bo Diao,Chenhui Wang,Yingjun Tan,Xiewan Chen,Ying Liu,Lifen Ning,Li Chen,Min Li,Yueping Liu,Gang Wang,Zilin Yuan,Zeqing Feng,Yi Zhang,Yuzhang Wu,Yongwen Chen +14 more
TL;DR: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted, and non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms.
Posted ContentDOI
Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)
Bo Diao,Chenhui Wang,Yingjun Tan,Xiewan Chen,Ying Liu,Lifen Ning,Li Chen,Min Li,Yueping Liu,Gang Wang,Zilin Yuan,Zeqing Feng,Yuzhang Wu,Yongwen Chen +13 more
TL;DR: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted, with patients in decline period showing reduced IL-6, IL-10 and TNF-α concentrations and restored T cell counts.
Posted ContentDOI
The Novel Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes
Yongwen Chen,Zeqing Feng,Bo Diao,Rongshuai Wang,Gang Wang,Chenhui Wang,Yingjun Tan,Liang Liu,Changsong Wang,Ying Liu,Yueping Liu,Zilin Yuan,Liang Ren,Yuzhang Wu +13 more
TL;DR: It is demonstrated that SARS-CoV-2 directly neutralizes human spleens and LNs through infecting tissue- resident CD169+ macrophage, and triggers macrophages to produce IL-6, a proinflammatory cytokine that directly promotes lymphocyte necrosis.
Journal ArticleDOI
Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection.
Bo Diao,Chenhui Wang,Rongshuai Wang,Zeqing Feng,Ji Zhang,Han Yang,Yingjun Tan,Huiming Wang,Changsong Wang,Liang Liu,Ying Liu,Yueping Liu,Gang Wang,Zilin Yuan,Xiaotao Hou,Liang Ren,Yuzhang Wu,Yongwen Chen +17 more
TL;DR: Wang et al. as mentioned in this paper performed a retrospective analysis of clinical parameters from 85 patients with laboratory-confirmed coronavirus disease 2019 (COVID-19); moreover, kidney histopathology from six additional COVID-2019 patients with post-mortem examinations was performed.
Journal ArticleDOI
Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells.
Yueping Liu,Yue Pan,Zhenhong Hu,Ming Wu,Chenhui Wang,Zeqing Feng,Congzheng Mao,Yingjun Tan,Ying Liu,Li Chen,Min Li,Gang Wang,Zilin Yuan,Bo Diao,Yuzhang Wu,Yongwen Chen +15 more
TL;DR: In this paper, the authors retrospectively reviewed the clinical outcomes of 76 severe COVID-19 cases admitted to 2 hospitals in Wuhan, China, from December 2019 to March 2020.