G
Gang Ye
Researcher at University of Louisville
Publications - 7
Citations - 491
Gang Ye is an academic researcher from University of Louisville. The author has contributed to research in topics: Diabetic cardiomyopathy & Contractility. The author has an hindex of 7, co-authored 7 publications receiving 465 citations.
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Journal ArticleDOI
Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes.
Gang Ye,Naira Metreveli,Rajakumar V. Donthi,Shen Xia,Ming Xu,Edward C. Carlson,Paul N. Epstein +6 more
TL;DR: Data show that both type 1 and type 2 diabetes induce damage at the level of individual myocytes, and that this damage occurs through mechanisms utilizing ROS.
Journal ArticleDOI
Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes
Jinhong Duan,Grant E. McFadden,Anthony J. Borgerding,Faye L. Norby,Bonnie H. Ren,Gang Ye,Paul N. Epstein,Jun Ren +7 more
TL;DR: The data suggest that elevated cardiac ACA exposure due to enhanced ADH expression may play an important role in the development of alcoholic cardiomyopathy.
Journal ArticleDOI
Cardiomyocyte dysfunction in models of type 1 and type 2 diabetes.
TL;DR: Though contractility is impaired in individual myocytes of db/db hearts and deficits are similar to what is seen in a severe model of type 1 diabetes, impairment in calcium reuptake is less severe, probably as a result of maintenance of normal levels of SERCA2a.
Journal ArticleDOI
Overexpression of hexokinase protects hypoxic and diabetic cardiomyocytes by increasing ATP generation.
TL;DR: Elevating hexokinase activity can be beneficial to hypoxic or diabetic cardiomyocytes secondary to improving myocyte ATP levels, as shown in myocytes from diabetic mice.
Journal ArticleDOI
Influence of gender on ethanol-induced ventricular myocyte contractile depression in transgenic mice with cardiac overexpression of alcohol dehydrogenase
Jinhong Duan,Lucy B. Esberg,Gang Ye,Anthony J. Borgerding,Bonnie H. Ren,Nicholas S. Aberle,Paul N. Epstein,Jun Ren +7 more
TL;DR: Data suggest that females may be more sensitive to ACA-induced cardiac contractile depression than male, which may attribute to the gender-related difference of alcoholic cardiomyopathy.