The invention discloses a sesquiterpenoid compound with a novel structure. The compound is names as (2R,3S)-2,3-dihydro-3-hydroxyl-6-isopropyl-2,4,7-trimethylindene-1-one, the molecular formula is C15H20O2, and the structure is represented in the description. The invention also discloses a preparation method and applications of the compound. The results of activity tests show that the compound has a good inhibiting effect on tobacco mosaic virus, and can be used as a lead compound for the research on drugs for preventing tobacco mosaic virus.

Sesquiterpenoid compound capable of inhibiting activity of tobacco mosaic virus in tobacco, preparation method and applications thereof

The invention discloses an intermediate of ecteinascidin-743 alkaloid, a synthesis method for the intermediate and an application of the intermediate. The compound is obtained through subjecting an aldehyde compound A and an amino-alcohol compound B to a Pictet-Spengler cyclization reaction in the presence or absence of a catalyst and a water absorbent. Through synthesizing ecteinascidin alkaloids by using the intermediate, the entire synthesis can have the advantages that the yield is ideal, the steps are simple, the raw materials and reagents are cheap, the conditions are moderate, the operation is simple and convenient, industrialization is easy to achieve, and the like. Compared with the existing synthesis of the ecteinascidin alkaloids, the method has the advantages that the cost is reduced effectively, and the efficiency is increased, thereby having a very good application prospect.

Intermediate of ecteinascidin-743 alkaloid, preparation method for intermediate and application of intermediate

The invention provides application of fluorenone compounds in dendrobe for preparing a drug for treating diabetes, and particularly provides application of a fluorenone compound shown in a formula IThe compound can be used for a hypoglycemic drug, a hypoglycemic healthcare food or a hypoglycemic food In the formula I, R1 and R2 are -H or -OH or -OCH3 The fluorenone compound is a natural compound existing in dendrobe and has the high alpha-glucosidase inhibitory activity, and the compound is adopted as the active ingredient and prepared into the hypoglycemic drug or the drug compound with pharmaceutically-acceptable carriers or accessories

Application of fluorenone compounds in dendrobe for preparing drug for treating diabetes and preparation method thereof

The invention discloses a tobacco feed liquid additive with anti-bacterial activity and application thereof. The tobacco feed liquid additive is prepared after glycerol, phenethyl alcohol, phenethyl acetate, vanillin, farnesol, phenylethyl propionate and rose flavone-S are uniformly and proportionally mixed. The rose flavone-S is a new flavonoid separated form waste residues which are obtained after rose essential oil is produced. The rose flavone-S is named as 2'-hydroxy-6-hydroxymethyl-7-methoxyflavone and has the structure shown in the description. When 5%-8% of the tobacco feed liquid additive is added into tobacco feed liquid, decomposition of the tobacco feed liquid is effectively inhibited, and the guarantee period of the tobacco feed liquid can be significantly prolonged. The throat comfort degree of cigarette smoking can be also improved, and the stimulation of smoking on the throat is reduced. The exquisite property and sweet sense of smoke are improved, and the smoke becomes smoother when passing through the throat and entering the nasal cavity. According to the tobacco feed liquid additive, the production technology is simple, sources of the raw materials are broad, the cost is low, additional values of rose processing are improved, waste resources are in comprehensive utilization, and the tobacco feed liquid additive has good application prospects.

Tobacco feed liquid additive with anti-bacterial activity and application thereof

The invention discloses a penicillium ester-III compound, and a preparation method, a preparation and application thereof. The penicillium ester-III compound is isolated from the endophytic fungus (Penicillium sp.) of Paris L., and has a molecular formula of C21H26O7. The structural formula of the compound is as described in the specification. The compound is named as penicillium ester-III. The preparation disclosed in the invention is a water aqua, a tablet, a granule or a microemulsion prepared by adding pharmaceutically acceptable adjuvants and/or an excipient to the penicillium ester-III compound. The application refers to the application of penicillium ester-III in the preparation of drugs for resisting tobacco mosaic viruses. Penicillium ester-III can not only significantly inhibit the initial infection of TMV on a host, but also has certain inactivation effect on TMV, thereby reducing the chance that viruses enter host cells and further replicates and propagates, so protection effect is performed on the host. The pharmaceutical preparation of the invention is non-toxic and harmless to human beings and animals, and safe and reliable to use, has good effect on preventing and treating tobacco mosaic virus diseases, and can be used for preparing pharmaceutical preparations applied to prevention and treatment of tobacco mosaic virus diseases.

Penicillium ester-III compound, and preparation method, preparation and application thereof

The invention discloses a xanthone compound as well as a preparation method and application of the xanthone compound. The xanthone compound has a structural formula shown in the specification, wherein R is -OH, a molecular formula of R is C17H1407, and the compound is named bracthone A; and R is -OMe, a molecular formula of R is C18H1607, and the compound is named bracthone B. The preparation method comprises the steps of: with branches, leaves and/or fruits ofdried garcinia arbor as raw materials, extracting extractum, carrying out extraction by using organic solvent, column chromatography on silica gels and high pressure liquid chromatography separation. The application refers to the application of the xanthone compound in preparation of anti-cancer drugs. The cytotoxic activity experiment shows that the bracthone A has high cytotoxic activity on NB4, A549 and PC3 cell strains; and the bracthone B has high cytotoxic activity on NB4, SHSY5Y, PC3 and MCF7. The xanthone compound has a simple structure, is good in activity, and be used as a guiding compound for anti-cancer drugs, and has good application prospect.

Xanthone compound as well as preparation method and application thereof

The invention discloses a hexacyclic alkaloid compound, a preparation method and an application thereof. The hexacyclic alkaloid compound is obtained through fermentation, extract extraction, chromatography and purification on a Penicilliumramigena (YNCA0361) strain, a molecular formula is C19H20N2O6, a structural formula is shown as the following, the compound is named as Penicilliumramigena A; a bacterial strain preservation number of the Penicilliumramigena (YNCA0361) strain is CGMCC No.4824, and the preservation date is 2nd, May, 2011. The preparation method comprises the steps of solid fermentation, extract extraction, slica column chromatography, and separation and purification by high pressure liquid chromatography. The application of the present invention is the application of the hexacyclic alkaloid compound for preparing tobacco mosaic virus medicines. The compound has good application prospect for preparing the tobacco mosaic virus medicines. The compound has good activity, and can be obtained through a biological fermentation approach, and can be used as the guiding compound for the tobacco mosaic virus medicines.

Hexacyclic alkaloid compound, preparation method and application thereof

The invention discloses benzofuran compound, and a preparation method and application thereof. The structural formula of the benzofuran compound is shown in the specification, wherein R is -OH; the molecular formula is C19H16O3; the compound is named gramniphenolF; R is -OMe; the molecular formula is C20H18O3; and the compound is named gramniphenolG. According to the preparation method, dried bamboo orchid branch, leaf and/or fruit are subjected to extractum extracting, organic solvent extracting, silica gelcolumn chromatography and high pressure liquid chromatography separation. The benzofuran compound can be applied to preparation of a drug for resisting tobacco mosaic virus. The inhibition ratios of the gramniphenolF and the gramniphenolG respectively reach 35.8+/-3.6% and 32.1+/-3.8% by an experiment of resistance to tobacco mosaic virus; the benzofuran compound has good activity of resisting the tobacco mosaic virus, and the inhibition ratio is higher than the inhibition ratio (31.8+/-2.5%) of a positive contrast Nanning mycin. The compound disclosed by the invention is simple in structure and good in single activity, can be used as a lead compound of the drug for resisting the tobacco mosaic virus, and has good application prospect.

Benzofuran compound, and preparation method and application thereof

The invention discloses fluorenone compounds and a preparation method and application thereof. According to the structural formulas of the fluorenone compounds, R1 is -H, R2 is -OH, a molecular formula is C19H18O6, and one compound is named as gramniphenol D; and R1 is -OH, R2 is -H, a molecular formula is C19H18O6, and the other compound is named as gramniphenol E. According to the preparation method, the fluorenone compounds are prepared from the raw materials including dried branches, leaves or fruits of arundina graminifolia. The preparation method comprises the steps of extract extraction, organic solvent extraction, silica column chromatography and high pressure liquid chromatography separation of the raw materials. The invention further discloses the application of the fluorenone compounds to preparation of anti-AIDS medicines. The gramniphenol D and the gramniphenol E are first detected natural fluorenone replaced by 2-hydroxy-3-methylbut-3-enyloxy. According to cytotoxicity detection on C8166 host cells and inhibition tests on an HIV-1IIIB-induced cytopathic effect (CPE) of the C8166, the two fluorenone compounds have good anti-HIV-1 activity, the EC50 values of the two fluorenone compounds are respectively 1.460.15 mug/mL and 1.580.20 mug/mL, and the therapeutic index (IT) values of the two fluorenone compounds are respectively 137 and 126.6. The fluorenone compounds have novel structures and high activity, and can serve as guiding compounds of the anti-AIDS medicines.

Fluorenone compounds and preparation method and application thereof

The invention discloses a biphenyl compound as well as a preparation method and an application thereof. The molecular formula of the biphenyl compound is C22H26O8, and the compound is named as neglignanD and has a structural formula shown in the specification. The preparation method comprises the following steps: performing extracting, organic solvent extracting, silicagel column chromatography, high performance liquid chromatography separation on the branches, leaves and fruit of dry schisandra chinensis which belong to macrophanerophytes and are used as raw materials. The application is the application of the biphenyl compound in preparing an anti-cancer drug. According to cytotoxic activity test, the neglignanD has good cytotoxic activity for cell strains such as NB4, A549, SHSY5Y, PC3 and MCF7. The compound disclosed by the invention is simple in structure, good in activity and good in application prospect and can be used as the pilot compound of the anti-cancer drug.

Gao Xuemei

Papers

Xanthone compound as well as preparation method and application thereof

Hexacyclic alkaloid compound, preparation method and application thereof

Benzofuran compound, and preparation method and application thereof

Fluorenone compounds and preparation method and application thereof

Biphenyl compound as well as preparation method and application thereof