Coumarin compound and preparation method and application thereof

The invention discloses a sesquiterpenoid compound with a novel structure. The compound is names as (2R,3S)-2,3-dihydro-3-hydroxyl-6-isopropyl-2,4,7-trimethylindene-1-one, the molecular formula is C15H20O2, and the structure is represented in the description. The invention also discloses a preparation method and applications of the compound. The results of activity tests show that the compound has a good inhibiting effect on tobacco mosaic virus, and can be used as a lead compound for the research on drugs for preventing tobacco mosaic virus.

Sesquiterpenoid compound capable of inhibiting activity of tobacco mosaic virus in tobacco, preparation method and applications thereof

The invention discloses sesquiterpenoids as well as a preparation method and an application thereof The sesquiterpenoids are obtained through separation from dry bark of Cassia fistula which is a medicinal plant used by the Dai people and belongs to the fabaceae, are named methyl 2-hydroxy-6-(hydroxymethyl)-4-isopropyl-7-methoxy-1-naphthoate, have the molecular formula of C17H20O5 and have a structure shown in the specification The preparation method of the sesquiterpenoids comprises the following steps: the dry bark of the Cassia fistula which is a medicinal plant used by the Dai people and belongs to the fabaceae is taken as a raw material, and the sesquiterpenoids are obtained through extraction of an extract, organic solvent extraction, MCI decoloration, slica-gel column chromatography and high pressure liquid chromatography separation Cytotoxicity experiments prove that the sesquiterpenoids have better cytotoxicity on part of tumor cell strains The compounds have novel structure and better biological activity and can be taken as lead compounds of anti-cancer drugs

Sesquiterpenoids as well as preparation method and application thereof

The invention discloses a benzofuran compound which has the structure as shown in the description. The compound is named as 2-(4-hydroxy-3,5-dimethoxy phenyl)-3-methyl-5-(3-isopentenyl)-benzofuran-7-ol, and the molecular formula of the compound is C22H24O5. The invention further discloses a preparation method of the benzofuran compound and application of the benzofuran compound in preparation of drugs for resisting a tobacco mosaic virus.

Benzofuran compound and preparation method thereof and application in preparation of drugs for resisting tobacco mosaic virus

The invention discloses norsesquiterpenoid compounds. The norsesquiterpenoid compounds are obtained through separation from bark of Cassia alata L. and named as 7-isopropyl-2,5-dimethoxy-1-methylnaphthalene and have a molecular formula of C16H20O2 and a structure shown in the specification. According to a preparation method of the norsesquiterpenoid compounds, the bark of Cassia alata L. is taken as a raw material and subjected to extract extraction, silica gel column chromatography and high-pressure liquid chromatography separation, and the norsesquiterpenoid compounds are obtained. An activity test of the norsesquiterpenoid compounds proves that the norsesquiterpenoid compounds have a good inhibition function on rotaviruses. The compounds have a novel structure and better antitoxic activity and can be used as lead compounds of a rotavirus pesticide.

Norsesquiterpenoid compounds as well as preparation method and application thereof

The invention discloses isoquinoline alkaloid compounds as well as a preparation method and application of the isoquinoline alkaloid compounds. The isoquinoline alkaloid compounds are separated from dried barks of leguminosae Cassia fistula serving as a medicinal plant in Dai nationality and have the molecular formula as follows: Cl4H15NO4, are named as fistulalkaloid A and have the structure as the specification. The preparation method of the isoquinoline alkaloid compounds comprises the steps of extract extraction, organic solvent extraction, MCI decoloration, silica column chromatography and high-performance liquid chromatography separation realized by taking the leguminosae Cassia fistula serving as the medicinal plant in Dai nationality as a raw material. Cytotoxic activity experiments prove that the isoquinoline alkaloid compounds have relatively good cytotoxic activity for parts of tumor cell strains. The compounds disclosed by the invention are novel in structure and relatively good in biological activity and can be used as lead compounds of anticancer drugs.

Isoquinoline alkaloid compounds as well as preparation method and application of isoquinoline alkaloid compounds

Aurone compound as well as preparation method and application thereof

The invention discloses benzofuran compound, and a preparation method and application thereof. The structural formula of the benzofuran compound is shown in the specification, wherein R is -OH; the molecular formula is C19H16O3; the compound is named gramniphenolF; R is -OMe; the molecular formula is C20H18O3; and the compound is named gramniphenolG. According to the preparation method, dried bamboo orchid branch, leaf and/or fruit are subjected to extractum extracting, organic solvent extracting, silica gelcolumn chromatography and high pressure liquid chromatography separation. The benzofuran compound can be applied to preparation of a drug for resisting tobacco mosaic virus. The inhibition ratios of the gramniphenolF and the gramniphenolG respectively reach 35.8+/-3.6% and 32.1+/-3.8% by an experiment of resistance to tobacco mosaic virus; the benzofuran compound has good activity of resisting the tobacco mosaic virus, and the inhibition ratio is higher than the inhibition ratio (31.8+/-2.5%) of a positive contrast Nanning mycin. The compound disclosed by the invention is simple in structure and good in single activity, can be used as a lead compound of the drug for resisting the tobacco mosaic virus, and has good application prospect.

Benzofuran compound, and preparation method and application thereof

The invention discloses an isobenzazole alkaloid compound. The isobenzazole alkaloid compound is extracted from the bark of medicinal plant Cassia alata L. of the Dai nationality, and is named as 5-(hydroxymethyl)-2-methyl-6-prenyl-isoindolin-1-one; the molecular formula is C15H19NO2; and the general structure is disclosed in the invention. The isobenzazole alkaloid compound is prepared by taking Cassia alata L. bark as a raw material via extraction, silica-gel column chromatography, and high performance liquid chromatography separation. It is shown by activity tests that the isobenzazole alkaloid compound possesses excellent inhibition effect on tobacco mosaic virus. The isobenzazole alkaloid compound is novel in structure, possesses excellent antiviral activity, and can be taken as a primer of drugs used for inhibiting tobacco mosaic virus.

Isobenzazole alkaloid compound, and preparation method and applications thereof

The invention discloses an indole alkaloid type compound and a preparation method and application thereof. The indole alkaloid type compound is separated from dry bark of the medicinal plant Cassia fistula of the Dai nationality, the compound is named as 2-(2-hydroxyethyl)-5-methyl-6-prenyl-isoindolin-1-one, the English name of the compound is 2-(2-hydroxyethyl)-5-methyl-6-prenyl-isoindolin-1-one, the molecular formula of the compound is C16H21NO2, and the structure of the compound can be seen in the description. The indole alkaloid type compound is prepared through the steps of extract exaction, organic solvent extraction, MCI decoloration, silica gelcolumn chromatography and high-pressure liquid chromatography with dry bark of the medicinal plant Cassia fistula of the Dai nationality as the raw material. It is shown through cytotoxic activity experiments that the indole alkaloid type compound has good cytotoxicity for part of tumor cell strains. The compound is novel in structure, has good biological activity and can be used as the lead compound of anti-cancer drugs.

Li Ganpeng

Papers

Isoquinoline alkaloid compounds as well as preparation method and application of isoquinoline alkaloid compounds

Aurone compound as well as preparation method and application thereof

Benzofuran compound, and preparation method and application thereof

Isobenzazole alkaloid compound, and preparation method and applications thereof

Indole alkaloid type compound and preparation method and application thereof