Gary Burgess

TL;DR: Among the 222 patients completing one year of treatment with sildenafil monotherapy, the improvement from baseline at one year in the distance walked in six minutes was 51 m, and the incidence of clinical worsening did not differ significantly between the patients treated with s Bildenafils and those treated with placebo.

TL;DR: A 16-week, double-blind, placebo-controlled, parallel-group study as discussed by the authors investigated the effect of adding oral sildenafil to long-term intravenous epoprostenol in patients with pulmonary arterial hypertension.

TL;DR: In patients with PAH-CTD, sildenafil improves exercise capacity, hemodynamic measures, and functional class after 12 weeks of treatment.

TL;DR: There is a mutual pharmacokinetic interaction between bosentan and sildenafil that may influence the dosage of each drug in a combination treatment, and further trials in patients with PAH are needed.

TL;DR: CPA fibrosis progression rate is a better predictor of clinical outcome than progression by Ishak stage, and histological de novo hepatitis, older donor age and non-use/discontinuation of azathioprine are associated with rapid Fibrosis progression in recurrent HCV chronic hepatitis after liver transplantation.