Gary S. Littman

TL;DR: These results demonstrate that robotic measures of motor performance will more than adequately capture outcome, and the altered effect size will reduce the required sample size.

TL;DR: The design, implementation, and outcome of an innovative Bayesian, response-adaptive, dose-ranging trial of an investigational drug in patients with diabetes, incorporating a dose expansion approach to flexibly address both efficacy and safety is reported.

TL;DR: The objective of the initiative was to test whether a small task force would be able to dramatically improve clinical development planning on a strategic level, and to integrate cross-functional expertise and to increase the information value per resource unit invested during drug development.

TL;DR: In this article, the authors used a combination of artificial ant colony and neural network ensembles to measure arm movement in 208 patients after acute ischemic stroke at two separate clinical sites.

TL;DR: What processes for interim monitoring, analysis, decision making and implementation, might be advantageous and appropriate for adaptive dose-ranging studies are discussed, and how processes were implemented and carried out in a particular case study are illustrated.