Institution
UCLA Medical Center
Healthcare•Santa Monica, California, United States•
About: UCLA Medical Center is a healthcare organization based out in Santa Monica, California, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 8526 authors who have published 10172 publications receiving 391108 citations.
Papers published on a yearly basis
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University of Calgary1, Maastricht University2, Erasmus University Rotterdam3, Royal Melbourne Hospital4, University of Amsterdam5, Bellvitge University Hospital6, Florey Institute of Neuroscience and Mental Health7, UCLA Medical Center8, University Hospital Bonn9, State University of New York System10, University of Toronto11, Beaumont Hospital12, Philadelphia College of Osteopathic Medicine13, Altair Engineering14, University of California, Los Angeles15, University of Pittsburgh16
TL;DR: Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location, and will have global implications on structuring systems of care to provide timely treatment.
4,846 citations
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McMaster University1, American University of Beirut2, University of Alcalá3, University of Geneva4, Leiden University Medical Center5, Virginia Commonwealth University6, University of California, San Diego7, Ohio State University8, University of Utah9, UCLA Medical Center10, Ottawa Hospital Research Institute11, Uniformed Services University of the Health Sciences12
TL;DR: Recommendations on 12 topics that were in the 9th edition of these guidelines are updated, and 3 new topics are addressed.
3,934 citations
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TL;DR: MRSA is the most common identifiable cause of skin and soft-tissue infections among patients presenting to emergency departments in 11 U.S. cities and clinicians should consider obtaining cultures and modifying empirical therapy to provide MRSA coverage.
Abstract: BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA. METHODS We enrolled adult patients with acute, purulent skin and soft-tissue infections presenting to 11 university-affiliated emergency departments during the month of August 2004. Cultures were obtained, and clinical information was collected. Available S. aureus isolates were characterized by antimicrobial-susceptibility testing, pulsed-field gel electrophoresis, and detection of toxin genes. On MRSA isolates, we performed typing of the staphylococcal cassette chromosome mec (SCCmec), the genetic element that carries the mecA gene encoding methicillin resistance. RESULTS S. aureus was isolated from 320 of 422 patients with skin and soft-tissue infections (76 percent). The prevalence of MRSA was 59 percent overall and ranged from 15 to 74 percent. Pulsed-field type USA300 isolates accounted for 97 percent of MRSA isolates; 74 percent of these were a single strain (USA300-0114). SCCmec type IV and the Panton-Valentine leukocidin toxin gene were detected in 98 percent of MRSA isolates. Other toxin genes were detected rarely. Among the MRSA isolates, 95 percent were susceptible to clindamycin, 6 percent to erythromycin, 60 percent to fluoroquinolones, 100 percent to rifampin and trimethoprim-sulfamethoxazole, and 92 percent to tetracycline. Antibiotic therapy was not concordant with the results of susceptibility testing in 100 of 175 patients with MRSA infection who received antibiotics (57 percent). Among methicillin-susceptible S. aureus isolates, 31 percent were USA300 and 42 percent contained pvl genes. CONCLUSIONS MRSA is the most common identifiable cause of skin and soft-tissue infections among patients presenting to emergency departments in 11 U.S. cities. When antimicrobial therapy is indicated for the treatment of skin and soft-tissue infections, clinicians should consider obtaining cultures and modifying empirical therapy to provide MRSA coverage.
2,096 citations
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TL;DR: Hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects and exhibited antifungal activity against Candida albicans, Aspergillus fumigatus, and As pergillus nigerand antibacterial activity against Escherichia coli.
2,063 citations
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TL;DR: The Test of Functional Health Literacy in Adults (TOFHLA) as mentioned in this paper was developed using actual hospital materials and consists of a 50-item reading comprehension and 17-item numerical ability test.
Abstract: OBJECTIVE: To develop a valid, reliable instrument to measure the functional health literacy of patients. DESIGN: The Test of Functional Health Literacy in Adults (TOFHLA) was developed using actual hospital materials. The TOFHLA consists of a 50-item reading comprehension and 17-item numerical ability test, taking up to 22 minutes to administer. The TOFHLA, the Wide Range Achievement Test-Revised (WRAT-R), and the Rapid Estimate of Adult Literacy in Medicine (REALM) were administered for comparison. A Spanish version was also developed (TOFHLA-S). SETTING: Outpatient settings in two public teaching hospitals. PATIENTS: 256 English- and 249 Spanish-speaking patients were approached. 78% of the English- and 82% of the Spanish-speaking patients gave informed consent, completed a demographic survey, and took the TOFHLA or TOFHLA-S. RESULTS: The TOFHLA showed good correlation with the WRAT-R and the REALM (correlation coefficients 0.74 and 0.84, respectively). Only 52% of the English speakers completed more than 80% of the questions correctly. 15% of the patients could not read and interpret a prescription bottle with instructions to take one pill by mouth four times daily, 37% did not understand instructions to take a medication on an empty stomach, and 48% could not determine whether they were eligible for free care. CONCLUSIONS: The TOFHLA is a valid, reliable indicator of patient ability to read health-related materials. Data suggest that a high proportion of patients cannot perform basic reading tasks. Additional work is needed to determine the prevalence of functional health illiteracy and its effect on the health care experience.
1,932 citations
Authors
Showing all 8556 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
Paul M. Thompson | 183 | 2271 | 146736 |
Bruce L. Miller | 163 | 1153 | 115975 |
Gregg C. Fonarow | 161 | 1676 | 126516 |
Barbara E.K. Klein | 160 | 856 | 93319 |
Jerome I. Rotter | 156 | 1071 | 116296 |
Howard L. Weiner | 144 | 1047 | 91424 |
Michael E. Phelps | 144 | 637 | 77797 |
Tomas Ganz | 141 | 480 | 73316 |
Antoni Ribas | 132 | 660 | 99227 |
George A. Bray | 131 | 896 | 100975 |
Jonathan Fulcher | 131 | 1216 | 83068 |
Richard N. Bergman | 130 | 477 | 91718 |
Michael Levine | 129 | 586 | 55963 |
Aldons J. Lusis | 127 | 673 | 73786 |