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Gaurav Bedse
Researcher at Vanderbilt University
Publications - 31
Citations - 1252
Gaurav Bedse is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Basolateral amygdala & Alcohol use disorder. The author has an hindex of 19, co-authored 31 publications receiving 990 citations. Previous affiliations of Gaurav Bedse include Sapienza University of Rome & Vanderbilt University Medical Center.
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Journal ArticleDOI
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
TL;DR: Considering that insulin mitigates beta-amyloid deposition and phosphorylation of tau, pharmacological strategies restoring brain insulin signaling, such as intranasal delivery of insulin, could have significant therapeutic potential in AD treatment.
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The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease
TL;DR: The role of endocannabinoid signaling in AD is recapitulate and the probable mechanisms through which modulators of the endOCannabinoid system provide their effects are highlighted, thus highlighting how this target might provide more advantages over other therapeutic targets.
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Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease.
Adele Romano,Lorenzo Pace,Bianca Tempesta,Angelo Michele Lavecchia,Teresa Macheda,Gaurav Bedse,Antonio Petrella,Carlo Cifani,Gaetano Serviddio,Gianluigi Vendemiale,Silvana Gaetani,Tommaso Cassano +11 more
TL;DR: It is suggested that 3×Tg-AD mice exhibit changes in depression-related behavior involving aminergic neurotrasmitters and provide an animal model for investigating AD with depression.
Journal ArticleDOI
Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.
Gaurav Bedse,Nolan D. Hartley,Nolan D. Hartley,Emily Neale,Andrew D. Gaulden,Toni A. Patrick,Philip J. Kingsley,Md. Jashim Uddin,Niels Plath,Lawrence J. Marnett,Sachin Patel,Sachin Patel +11 more
TL;DR: A pharmacological and functional redundancy between these canonical eCB signaling pathways exists in the modulation of anxiety-like behaviors and suggest a potentially wider therapeutic overlap between AEA and 2-AG augmentation approaches than was previously appreciated.
Journal ArticleDOI
Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.
Gaurav Bedse,Rebecca J. Bluett,Rebecca J. Bluett,Toni A. Patrick,Nicole K. Romness,Andrew D. Gaulden,Philip J. Kingsley,Niels Plath,Lawrence J. Marnett,Sachin Patel,Sachin Patel +10 more
TL;DR: Results showed that increasing either endogenous AEA or 2-AG separately produces anti-anxiety effects under stressful conditions but the same effects are not obtained from simultaneously increasing both AEA and 2- AG.