G
Gaylen M. Zentner
Researcher at Merck & Co.
Publications - 26
Citations - 2028
Gaylen M. Zentner is an academic researcher from Merck & Co.. The author has contributed to research in topics: Controlled release & Solubility. The author has an hindex of 18, co-authored 26 publications receiving 2017 citations.
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Patent
Swelling modulated polymeric drug delivery device
TL;DR: In this article, a controlled release drug delivery device, comprised of swellable polymers whose degree of swelling in an environment of use is controlled by swelling modulators blended within the polymers, is disclosed.
Patent
Controlled porosity osmotic pump
TL;DR: In this paper, an osmotic pump for the controlled release of diltiazem L-malate to an environment of use is presented, which consists of a core which comprises a therapeutically effective amount of DILM and an effective buffering amount of sodium bitartrate surrounded by a rate controlling water insoluble wall, having a fluid permeability of 6.96×10 -18 to 6.14 cm 3 sec/g and a reflection coefficient of less than 0.5.
Journal ArticleDOI
The controlled porosity osmotic pump
TL;DR: The zero-order release of water soluble, osmotically active agents from tablets coated with controlled porosity walls has been investigated in this article, where the walls were sponge-like in appearance and substantially permeable to both water and dissolved solutes.
Patent
Multiparticulate controlled porosity osmotic
TL;DR: In this paper, a multiparticulate osmotic pump for the controlled release of a pharmaceutically active agent to an environment of use is presented, which consists of a carrier medium which does not maintain its integrity in the environment, and a multiple of tiny pump elements each consisting essentially of: (a) a core comprising at least one pharmacologically active agent soluble in an external fluid, or a mixture of an agent having a limited solubility in the external fluid with an osmotically effective solute that is soluble in the fluid, which exhibit an
Journal ArticleDOI
Osmotic flow through controlled porosity films: An approach to delivery of water soluble compounds
TL;DR: The zero-order release of water soluble, osmotically active agents from tablets coated with controlled porosity walls has been investigated in this article, where the walls were sponge-like in appearance and substantially permeable to both water and dissolved solutes.