Journal ArticleDOI
Osmotic flow through controlled porosity films: An approach to delivery of water soluble compounds
TLDR
The zero-order release of water soluble, osmotically active agents from tablets coated with controlled porosity walls has been investigated in this article, where the walls were sponge-like in appearance and substantially permeable to both water and dissolved solutes.About:
This article is published in Journal of Controlled Release.The article was published on 1985-11-01. It has received 104 citations till now. The article focuses on the topics: Osmotic pressure.read more
Citations
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Journal ArticleDOI
Cyclodextrin-based controlled drug release system.
Fumitoshi Hirayama,Kaneto Uekama +1 more
TL;DR: In an oral drug delivery system (DDS), the hydrophilic and ionizable CDs can serve as potent drug carriers in the immediate release- and delayed release-formulations, respectively, while the release rate of water-soluble drugs can be retarded by hydrophobic CDs.
Patent
Drug delivery systems
TL;DR: A photoactivatable drug delivery system is provided, in which a drug is combined e.g. by covalent bonding, incorporation in a matrix or encapsulation, with a photosensitive macromolecule so that the combination can be implanted at a location of maximum effectiveness.
Journal ArticleDOI
Formulation aspects in the development of osmotically controlled oral drug delivery systems.
TL;DR: By optimizing formulation and processing factors, it is possible to develop osmotic systems to deliver drugs of diverse nature at a pre-programmed rate.
Book
Drug Discovery and Development
TL;DR: The process of drug discovery involves a melding of many disciplines and interests, transcending the relatively simple process of identifying an active compound in the test tube and must be relatively free of toxicity, bioavailable, and marketable before it can be considered to be a therapeutic entity.
Patent
Self-destructing, controlled release peroral drug delivery system
TL;DR: In this paper, a modified release drug delivery system, for once a day peroral use, consisting of a solid core comprising an active agent together with a hydrogel, with the solid core being optionally drilled to provide a release orifice, and then optionally further coated with the same or different active agent material.
References
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Journal ArticleDOI
Elementary osmotic pump.
TL;DR: The elementary osmotic pump is a new delivery system for drugs or other active agents; it delivers the agent by an osmosis process at a controlled rate and the release rate was found to be independent of outside agitation when the system is not deformed by shaking action.