G
Gen Inoue
Researcher at Kitasato University
Publications - 347
Citations - 7267
Gen Inoue is an academic researcher from Kitasato University. The author has contributed to research in topics: Medicine & Lumbar. The author has an hindex of 41, co-authored 294 publications receiving 5735 citations. Previous affiliations of Gen Inoue include Chiba University.
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Journal ArticleDOI
Tumor necrosis factor-immunoreactive cells and PGP 9.5-immunoreactive nerve fibers in vertebral endplates of patients with discogenic low back Pain and Modic Type 1 or Type 2 changes on MRI.
Seiji Ohtori,Gen Inoue,Toshinori Ito,Takana Koshi,Tomoyuki Ozawa,Hideo Doya,Tomoko Saito,Hideshige Moriya,Kazuhisa Takahashi +8 more
TL;DR: The results suggest that endplate abnormalities are related to inflammation and axon growth induced by TNF.
Journal ArticleDOI
Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective.
Seiji Ohtori,Gen Inoue,Sumihisa Orita,Kazuyo Yamauchi,Yawara Eguchi,Nobuyasu Ochiai,Shunji Kishida,Kazuki Kuniyoshi,Yasuchika Aoki,Junichi Nakamura,Tetsuhiro Ishikawa,Masayuki Miyagi,Hiroto Kamoda,Miyako Suzuki,Gou Kubota,Yoshihiro Sakuma,Yasuhiro Oikawa,Kazuhide Inage,Takeshi Sainoh,Masashi Takaso,Tomoaki Toyone,Kazuhisa Takahashi +21 more
TL;DR: Administration of teriparatide increased the quality of the lumbar spine bone marrow and pedicle cortex, and the extent of PS loosening in the risedronate group was not significantly different from that in the control group.
Journal ArticleDOI
Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.
Sumihisa Orita,Tetsuhiro Ishikawa,Masayuki Miyagi,Nobuyasu Ochiai,Gen Inoue,Yawara Eguchi,Hiroto Kamoda,Gen Arai,Tomoaki Toyone,Yasuchika Aoki,Takekazu Kubo,Kazuhisa Takahashi,Seiji Ohtori +12 more
TL;DR: Pain-related characteristics in a MIA-induced rat OA model can originate from an inflammatory pain state induced by the local inflammation initiated by inflammatory cytokines, and that state will be followed by gradual initiation of neuronal injury, which may induce the neuropathic pain state.
Journal ArticleDOI
Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee.
Sumihisa Orita,Takana Koshi,Takeshi Mitsuka,Masayuki Miyagi,Gen Inoue,Gen Arai,Tetsuhiro Ishikawa,Eiji Hanaoka,Keishi Yamashita,Masaomi Yamashita,Yawara Eguchi,Tomoaki Toyone,Kazuhisa Takahashi,Seiji Ohtori +13 more
TL;DR: The present study demonstrated that the concentrations of proinflammatory cytokines are correlated with KL grades and WOMAC scores in patients with knee OA, and these cytokines play a role in the pathogenesis of synovitis in osteoarthritic knees in different ways.
Journal ArticleDOI
Teriparatide accelerates lumbar posterolateral fusion in women with postmenopausal osteoporosis: prospective study.
Seiji Ohtori,Gen Inoue,Sumihisa Orita,Kazuyo Yamauchi,Yawara Eguchi,Nobuyasu Ochiai,Shunji Kishida,Kazuki Kuniyoshi,Yasuchika Aoki,Junichi Nakamura,Tetsuhiro Ishikawa,Masayuki Miyagi,Hiroto Kamoda,Miyako Suzuki,Gou Kubota,Yoshihiro Sakuma,Yasuhiro Oikawa,Kazuhide Inage,Takeshi Sainoh,Masashi Takaso,Tomoyuki Ozawa,Kazuhisa Takahashi,Tomoaki Toyone +22 more
TL;DR: Daily subcutaneous injection of teriparatide for bone union using local bone grafting after instrumented lumbar posterolateral fusion in women with postmenopausal osteoporosis was more effective than oral administration of bisphosphonate.