G
Geneviève Nguyen
Researcher at French Institute of Health and Medical Research
Publications - 53
Citations - 5294
Geneviève Nguyen is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Renin–angiotensin system & Receptor. The author has an hindex of 29, co-authored 53 publications receiving 5056 citations. Previous affiliations of Geneviève Nguyen include Institut Gustave Roussy & Collège de France.
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Journal ArticleDOI
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
Geneviève Nguyen,Françoise Delarue,Céline Burcklé,Latifa Bouzhir,Thomas Giller,Jean-Daniel Sraer +5 more
TL;DR: The expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single transmembrane domain and no homology with any known membrane protein is reported, the first described for an aspartyl protease.
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3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Increase Fibrinolytic Activity in Rat Aortic Endothelial Cells Role of Geranylgeranylation and Rho Proteins
Marie Essig,Geneviève Nguyen,Dominique Prié,Brigitte Escoubet,Jean-Daniel Sraer,Gérard Friedlander +5 more
TL;DR: HRI can modify the fibrinolytic potential of endothelial cells, likely via inhibition of geranylgeranylated Rho protein and disruption of the actin filaments.
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Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats
David Louis Feldman,Liang Jin,Hong Xuan,Aurelie Contrepas,Yinong Zhou,Randy Lee Webb,Dominik N Mueller,Sandra Feldt,Frederick Cumin,Wieslawa Maniara,Elke Persohn,Helmut Schuetz,A.H. Jan Danser,Geneviève Nguyen +13 more
TL;DR: The evidence that aliskiren can reduce in vivo gene expression for the (pro)renin receptor and that it may block prorenin-induced angiotensin generation supports the need for additional work to reveal the mechanism of the observed renoprotection by this renin inhibitor.
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Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma
Christelle Cousin,Diane Bracquart,Aurelie Contrepas,Pierre Corvol,Laurent Muller,Geneviève Nguyen +5 more
TL;DR: Results show that s(P)RR is generated intracellularly by furin cleavage, and that the existence of circulating s( P)RR detected in plasma is able to bind renin.
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Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen
TL;DR: It is shown that human mesangial cells in culture express a specific receptor for renin, and that the binding of renin increases 3H thymidine incorporation independently of renIn enzymatic activity.