Geng-Xian Zhao

TL;DR: The Annonaceous acetogenins as mentioned in this paper are a class of bioactive natural products whose antitumour, pesticidal and other bioactivities are due to inhibition of electron transport in mitochondria.

TL;DR: Fractionation of the EtOH extract of the bark of Asimina triloba has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin.

TL;DR: Bioactivities of the isolated compounds against brine shrimp, yellow fever mosquito larvae, and human tumor cells are reported; compound 4 was the most bioactive, showing selectivity for the human colon tumor cell line (HT-29).

TL;DR: The leaves of Annona muricata have yielded eight monotetrahydrofuran Annonaceous acetogenins; two of them, annomuricins A and B, are novel and unusual.

TL;DR: The activities of 44 Annonaceous acetogenins, which were originally isolated by monitoring plant fractionations with the brine shrimp lethality test (BST), were evaluated in the yellow fever mosquito larvae microtiter plate (YFM) assay, showing the first report of pesticidal structure–activity relationships.