Journal ArticleDOI
Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba.
TLDR
Fractionation of the EtOH extract of the bark of Asimina triloba has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin.Abstract:
Fractionation of the EtOH extract of the bark of Asimina triloba, monitoring by brine shrimp lethality, has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin [1], in addition to six known compounds: asimicin 2], bullatacin [3], bullatacinone [4], N-p-coumaroyltyramine [5], N-trans-feruloyltyramine [6], and (+)-syringaresinol [7]. Acetogenin 1 was identified as a diastereomer of asimicin [2] by spectral and chemical methods, and both 1 and 2 showed potent and selective cytotoxicities in the NCI human tumor cell line screen.read more
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Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products⊥
TL;DR: Activity-directed fractionation of the paw paw extracts led to the isolation and molecular characterization of over 50 unique annonaceous acetogenins, which indicated a myriad of potentially useful applications.
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Annonaceous acetogenins: An updated review
TL;DR: The Annonaceous acetogenins as mentioned in this paper are a class of bioactive natural products whose antitumour, pesticidal and other bioactivities are due to inhibition of electron transport in mitochondria.
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Acetogenins from annonaceae, inhibitors of mitochondrial complex I
TL;DR: These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain) of the Annonaceae.
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Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae)
TL;DR: This comprehensive study could lay the foundation for further research on the Lycium genus and enumerated 355 chemical constituents and nutrients.
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Accumulation of feruloyltyramine and p-coumaroyltyramine in tomato leaves in response to wounding
TL;DR: A role for hydroxycinnamate-tyramine conjugates as part of the array of defense chemicals and protective biopolymers induced in leaves and other plant tissues by wounding, to protect the plants against pathogen and herbivore attacks is supported.