G
Gennaro Melino
Researcher at University of Rome Tor Vergata
Publications - 87
Citations - 4170
Gennaro Melino is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Cellular differentiation & Apoptosis. The author has an hindex of 31, co-authored 84 publications receiving 3879 citations. Previous affiliations of Gennaro Melino include Medical Research Council & Saint Petersburg State Institute of Technology.
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Journal ArticleDOI
miR-203 represses 'stemness' by repressing DeltaNp63.
Anna Maria Lena,Ruby Shalom-Feuerstein,P. Rivetti di Val Cervo,Daniel Aberdam,Richard A. Knight,Gennaro Melino,Gennaro Melino,E Candi +7 more
TL;DR: The results suggest that miR-203, by regulating the ΔNp63 expression level, is a key molecule controlling the p63-dependent proliferative potential of epithelial precursor cells both during keratinocyte differentiation and in epithelial development.
Journal ArticleDOI
Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.
Tobias J. Grob,Urban Novak,C Maisse,Daniela Barcaroli,A U Lüthi,F Pirnia,Barbara Hügli,Hans U. Graber,V De Laurenzi,Martin F. Fey,Gennaro Melino,Andreas Tobler +11 more
TL;DR: Interestingly, expression of the ΔNp73 is strongly up-regulated by the TA isoforms and by p53, thus creating a feedback loop that tightly regulates the function of TAp73 and more importantly of p53.
Journal ArticleDOI
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
Paola Tucci,Massimiliano Agostini,Francesca Grespi,Francesca Grespi,Francesca Grespi,E K Markert,Alessandro Terrinoni,Karen H. Vousden,Patricia A.J. Muller,Volker Dötsch,Sebastian Kehrloesser,Berna S. Sayan,Giuseppe Giaccone,Scott W. Lowe,Nozomi Takahashi,Nozomi Takahashi,Peter Vandenabeele,Peter Vandenabeele,Richard A. Knight,Arnold J. Levine,Gennaro Melino,Gennaro Melino,Gennaro Melino +22 more
TL;DR: It is suggested that p63/miR-205 may be a useful clinical predictor of metastatic behavior in prostate cancer and loss of this axis was associated with higher Gleason scores, an increased likelihood of metastasis and infiltration events, and worse prognosis.
Journal ArticleDOI
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.
TL;DR: It is shown that in intact cells caspase-7 can also directly process and activate casp enzyme-2 and -6, and this possibility in cells induced to undergo apoptosis by activation of the intrinsic pathway is examined.
Journal Article
The expression of "tissue" transglutaminase in two human cancer cell lines is related with the programmed cell death (apoptosis).
Mauro Piacentini,László Fésüs,Maria Grazia Farrace,Lina Ghibelli,Lucia Piredda,Gennaro Melino +5 more
TL;DR: Data indicate that also in tumors tTG activation takes place in cells undergoing apoptosis, and the number of insoluble protein envelopes as well as the N,N-bis(gamma-glutamyl)polyamine cross-links is related with both tTG expression and apoptotic index, strongly suggesting the participation of the enzyme in the apoptotic program.