Geoff G. Z. Zhang

TL;DR: The basic principles of polymorphism are reviewed, the classes of phase transformation and the underlying transformation mechanisms are defined, and respective kinetic factors are discussed.

TL;DR: The dissolution advantage of amorphous solids can be negated either by crystallization of the isomorphous solid on contact with the dissolution medium or through rapid crystallizationof the supersaturated solution.

TL;DR: Crystallization studies under nonisothermal conditions revealed that compounds with the highest entropic barriers and lowest mobilities were most difficult to crystallize, regardless of the thermodynamic driving forces.

TL;DR: The concepts of solubility, supersaturation, and the connection to membrane transport rate are discussed and it is believed that formulations that rapidly supersaturate and subsequently undergo LLPS, with maintenance of the supersaturation at this maximum value throughout the absorption process, will give superior performance in terms of absorption.

TL;DR: The supersaturation generated upon dissolution of the solid dispersions was maintained for biologically relevant timeframes for the HPMC dispersions, whereas PVP appeared to be a less effective crystallization inhibitor.