G
Geoffrey W. McCaughan
Researcher at Royal Prince Alfred Hospital
Publications - 560
Citations - 23909
Geoffrey W. McCaughan is an academic researcher from Royal Prince Alfred Hospital. The author has contributed to research in topics: Liver transplantation & Transplantation. The author has an hindex of 75, co-authored 524 publications receiving 21798 citations. Previous affiliations of Geoffrey W. McCaughan include Alfred Hospital & Fairfield Hospital.
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Journal ArticleDOI
Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
Minoti V. Apte,Paul S. Haber,Tanya L. Applegate,Ian D. Norton,Geoffrey W. McCaughan,Mark A. Korsten,Ron Pirola,Jeremy S. Wilson +7 more
TL;DR: Cells resembling hepatic stellate cells are present in rat pancreas in a number comparable with that of stellates cells in the liver, and these stellated shaped pancreatic cells can be isolated and cultured in vitro.
Journal ArticleDOI
Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression
Jason M. Hui,Archana Sud,Geoffrey C. Farrell,Priyanka Bandara,Karen Byth,James G. Kench,Geoffrey W. McCaughan,Jacob George +7 more
TL;DR: The hypothesis that insulin resistance may contribute to fibrotic progression in chronic hepatitis C virus infection is supported, and the effect seems to be genotype specific.
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Hepascore: An Accurate Validated Predictor of Liver Fibrosis in Chronic Hepatitis C Infection
Leon A. Adams,Max Bulsara,Enrico Rossi,Bastiaan DeBoer,David J. Speers,Jacob George,James G. Kench,Geoffrey C. Farrell,Geoffrey W. McCaughan,Gary P. Jeffrey,Gary P. Jeffrey +10 more
TL;DR: A model of 4 serum markers plus age and sex provides clinically useful information regarding different fibrosis stages among hepatitis C patients.
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Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis
Minoti V. Apte,Paul S. Haber,S J Darby,S C Rodgers,Geoffrey W. McCaughan,Mark A. Korsten,Ron Pirola,Jeremy S. Wilson +7 more
TL;DR: An important role for stellate cells in pancreatic fibrogenesis is suggested by results suggesting an important response to the cytokines PDGF and TGF-β by increased proliferation and increased collagen synthesis.
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Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines
TL;DR: The progressive liver injury seen in chronic HCV is associated with the upregulation of intrahepatic Th1‐like cytokines and the downregulation of IL‐10, a Th2‐ like cytokine, which suggests a role for delayed‐type hypersensitivity immune reactions in HCV related liver injury.