G
George Albers-Schonberg
Researcher at Merck & Co.
Publications - 18
Citations - 3258
George Albers-Schonberg is an academic researcher from Merck & Co.. The author has contributed to research in topics: Streptomyces avermitilis & Aspergillus terreus. The author has an hindex of 16, co-authored 18 publications receiving 3192 citations.
Papers
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Journal ArticleDOI
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Alfred W. Alberts,Julie S. Chen,G Kuron,V Hunt,Jesse W. Huff,Carl H. Hoffman,John W. Rothrock,Lopez Maria B,Henry Joshua,Elbert E. Harris,Arthur A. Patchett,R L Monaghan,S Currie,E Stapley,George Albers-Schonberg,Otto D. Hensens,J Hirshfield,Karst Hoogsteen,Jerrold M. Liesch,James P. Springer +19 more
TL;DR: It was shown that mevinolin was an orally active cholesterol-lowering agent in the dog and orally administered sodium mevinolinate was an active inhibitor of cholesterol synthesis in an acute assay.
Patent
Hypocholesteremic fermentation products and process of preparation
TL;DR: In this paper, the authors describe a class of highly active hypocholesteremic and hypolipemic medicaments, which are derived from a microorganism belonging to the genus Aspergillus.
Journal ArticleDOI
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
RS Chang,VJ Lotti,Richard L. Monaghan,Jerome Birnbaum,Edward O. Stapley,Michael A. Goetz,George Albers-Schonberg,Arthur A. Patchett,Jerrold M. Liesch,Otto D. Hensens +9 more
TL;DR: A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus and has 300 to 400 times the affinity for pancreatic, ileal, and gallbladder CCK receptors than proglumide, a standard agent of this class.
Patent
Novel substances and process for their production
TL;DR: In this paper, the authors describe C-076, a compound produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis.
Journal ArticleDOI
Phosphonomycin: Structure and Synthesis
B. G. Christensen,William J. Leanza,Thomas R. Beattie,Arthur A. Patchett,Byron H. Arison,Robert E. Ormond,Frederick A. Kuehl,George Albers-Schonberg,O. Jardetzky +8 more
TL;DR: Synthesis and resolution of the antibiotic phosphonomycin are described and the structure is (—)(IR, 2S)-1,2-epoxypropylphosphonic acid.