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Byron H. Arison
Researcher at Merck & Co.
Publications - 243
Citations - 6358
Byron H. Arison is an academic researcher from Merck & Co.. The author has contributed to research in topics: Metabolite & Coenzyme Q – cytochrome c reductase. The author has an hindex of 40, co-authored 243 publications receiving 6211 citations. Previous affiliations of Byron H. Arison include United States Military Academy & University of Massachusetts Boston.
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Journal ArticleDOI
A potent cyclic hexapeptide analogue of somatostatin
Daniel F. Veber,Freidlinger Rm,Debra S. Perlow,William J. Paleveda,Frederick W. Holly,Robert G. Strachan,Ruth F. Nutt,Byron H. Arison,Carl F. Homnick,W.C. Randall,Monroe S. Glitzer,Richard Saperstein,Hirschmann Ralph F +12 more
TL;DR: A computer modelling and graphics system is used to examine possible alternative molecular fragments and report the synthesis of a highly active cyclic hexapeptide analogue of somatostatin, which results in the observed reduced susceptibility to metabolism by peptidases such as trypsin and has permitted both a long duration of action and oral activity.
Journal Article
In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450S
Thomayant Prueksaritanont,Lynn M. Gorham,Bennett Ma,Lida Liu,Xiao Yu,Jianguo J. Zhao,Donald E. Slaughter,Byron H. Arison,Kamlesh P. Vyas +8 more
TL;DR: It is concluded that CYP3A is the major enzyme subfamily responsible for the metabolism of SV by human liver microsomes, and metabolic activities mediated by the other P450 enzymes tested are unlikely to be affected by SV.
Journal ArticleDOI
De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing beta-D-glucose as a novel scaffolding
Ralph Hirschmann,Kyriacos C. Nicolaou,S. Pietranico,E. M. Leahy,J. Salvino,Byron H. Arison,Maria A. Cichy,P. Grant Spoors,William C. Shakespeare +8 more
TL;DR: Unexpectedly, it is found that the primary amino group of Lys 9 is not required for SRIF receptor binding or activation, and its potential implications are discussed.