G
George Appiah-Kubi
Researcher at Ohio State University
Publications - 2
Citations - 260
George Appiah-Kubi is an academic researcher from Ohio State University. The author has contributed to research in topics: Endosome & Vesicle. The author has an hindex of 2, co-authored 2 publications receiving 202 citations.
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Journal ArticleDOI
Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides
Ziqing Qian,Agnieszka Martyna,Ryan L. Hard,Jiang Wang,George Appiah-Kubi,Christopher C. Coss,Mitch A. Phelps,Jeremy S. Rossman,Dehua Pei +8 more
TL;DR: Data suggest that cyclic CPPs exit the endosome by binding to the endOSomal membrane and inducing CPP-enriched lipid domains to bud off as small vesicles, which should provide a powerful system for intracellular delivery of therapeutic agents and chemical probes.
Journal ArticleDOI
Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization.
Ziqing Qian,Curran A. Rhodes,Lucas C. McCroskey,Jin Wen,George Appiah-Kubi,David J. Wang,Denis C. Guttridge,Dehua Pei +7 more
TL;DR: A general, reversible bicyclization strategy is now reported to increase both the proteolytic stability and cell permeability of peptidyl drugs.