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Agnieszka Martyna
Researcher at University of Kent
Publications - 6
Citations - 308
Agnieszka Martyna is an academic researcher from University of Kent. The author has contributed to research in topics: Membrane curvature & Membrane. The author has an hindex of 4, co-authored 6 publications receiving 230 citations.
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Journal ArticleDOI
Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides
Ziqing Qian,Agnieszka Martyna,Ryan L. Hard,Jiang Wang,George Appiah-Kubi,Christopher C. Coss,Mitch A. Phelps,Jeremy S. Rossman,Dehua Pei +8 more
TL;DR: Data suggest that cyclic CPPs exit the endosome by binding to the endOSomal membrane and inducing CPP-enriched lipid domains to bud off as small vesicles, which should provide a powerful system for intracellular delivery of therapeutic agents and chemical probes.
Journal ArticleDOI
Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission.
Agnieszka Martyna,Basma Bahsoun,Matthew D. Badham,Saipraveen Srinivasan,Mark J. Howard,Jeremy S. Rossman +5 more
TL;DR: It is shown that AHs in the cellular proteins Arf1 and Epsin1 behave in a similar manner, and represent a class of membrane-induced AH domains that alter membrane curvature and fluidity, mediating the scission of constricted membrane necks in multiple biological pathways.
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Curvature Sensing by a Viral Scission Protein
TL;DR: The results show that the M2AH senses membrane curvature and suggest that the AH domain may localize the protein at the viral neck where it can then mediate membrane scission and the release of budding viruses.
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Cholesterol Alters the Orientation and Activity of the Influenza Virus M2 Amphipathic Helix in the Membrane.
Agnieszka Martyna,Basma Bahsoun,Jesper J. Madsen,Frederic St. J.S. Jackson,Matthew D. Badham,Gregory A. Voth,Jeremy S. Rossman +6 more
TL;DR: Cholesterol regulates M2 membrane scission by precisely modulating M2AH positioning within the membrane, which has implications for the understanding of many of amphipathic-helix-driven cellular budding processes that occur in specific lipid environments.
Journal ArticleDOI
Alterations of membrane curvature during influenza virus budding.
TL;DR: In the later stages of budding, M2 is localized to the neck of the budding virion at the lipid phase boundary, where it causes negative membrane curvature, leading to scission and virion release.