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Showing papers by "George M. Happ published in 2000"

Journal Article•DOI•
Nomenclature for factors of the dog major histocompatibility system (DLA), 1998: first report of the ISAG DLA Nomenclature Committee.

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Lorna J. Kennedy1, Laura Altet2, J. M. Angles3, A. Barnes4, Stuart D. Carter4, Olga Francino2, John A. Gerlach5, George M. Happ6, W. E. R. Ollier1, A. Polvi7, Wendy Thomson1, John L. Wagner8 •
University of Manchester1, Autonomous University of Barcelona2, University of California, Davis3, University of Liverpool4, Michigan State University5, University of Alaska Fairbanks6, Finnish Red Cross7, Fred Hutchinson Cancer Research Center8
01 Jan 2000-Animal Genetics
TL;DR: A Nomenclature committee for Factors of the Dog Major Histocompatibility System or Dog Leukocyte Antigen (DLA) has been convened under the auspices of the International Society for Animal Genetics (ISAG) to define a sequence based nomenclatures for the genes of the DLA system.
Abstract: A Nomenclature committee for Factors of the Dog Major Histocompatibility System or Dog Leukocyte Antigen (DLA) has been convened under the auspices of the International Society for Animal Genetics (ISAG) to define a sequence based nomenclature for the genes of the DLA system. The remit of this committee includes: assignment of gene names rules for naming alleles assignment of names to published alleles assignment of names to new alleles rules for acceptance of new alleles DLA Nomenclature Committee, rules for acceptance, DLA genes and alleles, sequence based nomenclature.

70 citations

Book Chapter•DOI•
6 - Nomenclature for Factors of the Dog Major Histocompatibility System (DLA), 2000

[...]

Lorna J. Kennedy1, L. Altet2, J. M. Angles3, A. Barnes4, Stuart D. Carter4, Olga Francino5, John A. Gerlach6, George M. Happ7, W. E. R. Ollier1, A. Polvi8, Wendy Thomson1, John L. Wagner9 •
University of Manchester1, University College Dublin2, University of California, Davis3, University of Liverpool4, Autonomous University of Barcelona5, Michigan State University6, University of Alaska Fairbanks7, Finnish Red Cross8, Fred Hutchinson Cancer Research Center9
01 Feb 2000-Animal Genetics
TL;DR: This chapter provides nomenclature for factors of the dog histocompatibility system (DLA) and the principles established here for the Canidae group may have applications in other animals that have been domesticated.
Abstract: This chapter provides nomenclature for factors of the dog histocompatibility system (DLA). The Major Histocompatibility Complex (MHC) of the dog and other Canidae appear to be highly polymorphic; and alleles of these genes are likely to be functionally relevant in regulating the immune response and the susceptibility/resistance to immune-mediated diseases. Since the first nomenclature report, 48 DLA-88 , 16 DLADRB1 , 6 DLA-DQA1 , and 15 DLA-DQB1 alleles have been named. Although there is some evidence for 2, 3, and 4 alleles respectively for DLA-12 , DLA-64 , and DLA-79 , no sequence alignments have been published, and no alleles have been lodged in GenBank till date. The principles for naming the MHC genes and alleles in different Canidae, and its application to sub-species and hybrids, have been considered. The principles established here for the Canidae group may have applications in other animals that have been domesticated. Compelling evidence of MHC identity exists among these Canidae, because three locus haplotypes are shared among dogs, wolves, and coyotes.

13 citations