G
George N. Pavlakis
Researcher at National Institutes of Health
Publications - 283
Citations - 20389
George N. Pavlakis is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immune system & DNA vaccination. The author has an hindex of 72, co-authored 268 publications receiving 18970 citations. Previous affiliations of George N. Pavlakis include Government of the United States of America & Karolinska Institutet.
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Journal ArticleDOI
Automatic and Quantitative Measurement of Protein-Protein Colocalization in Live Cells
Sylvain V. Costes,Dirk Daelemans,Edward H. Cho,Zachary C. Dobbin,George N. Pavlakis,Stephen J. Lockett +5 more
TL;DR: A novel statistical approach that quantifies, for the first time, the amount of colocalization of two fluorescent-labeled proteins in an image automatically, removing the bias of visual interpretation is introduced.
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Improved DNA: liposome complexes for increased systemic delivery and gene expression.
Nancy Smyth Templeton,Danilo D. Lasic,Peter M. Frederik,Helmut H. Strey,David D. Roberts,George N. Pavlakis +5 more
TL;DR: Cryo-electron microscopy examination demonstrates that theDNA:liposome complexes have a novel morphology, and that the DNA is condensed on the interior of invaginated liposomes between two lipid bilayers, which could account for the high efficiency of gene delivery in vivo and for the broad tissue distribution of the DNA:lipo-somes complexes.
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rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.
Barbara K. Felber,Margarita Hadzopoulou-Cladaras,C Cladaras,Terry D. Copeland,George N. Pavlakis +4 more
TL;DR: The selective effects of rev on the levels of the viral mRNA suggest a model for feedback regulation by rev leading to a steady state of viral expression.
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The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats
TL;DR: Results indicate that the pX protein is essential for the replication cycle of the virus and that it may be directly involved in the immortalization of human lymphocytes by HTLV-I.
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Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1.
TL;DR: HIV-1 uses both alternatively spliced and bicistronic mRNAs for the production of Tat, Rev, and Nef proteins.