Showing papers by "George Stoica published in 2015"
1 citations
31 Dec 2015
TL;DR: The role of microenvironment in development of glioblastoma in the dog species as an animal model for human disease is reviewed for a better understanding of underlined mechanism(s) and possible target therapy for the benefit of both species.
Abstract: Understanding the cancer stem cells (CSCs) role in malignancy is based on a comprehensive understanding of normal stem cells role and plasticity in maintaining the normal homeostasis or regeneration in various organ tissues. The niche microenvironment that sustains and regulates stem cells is tightly regulated by physical factors and hormonal signals. In the central nervous system (CNS) malignancy the CSCs niche is deregulated by intrinsic and extrinsic factors, which disrupt the homeostatic balance from quiescence state to proliferation and differentiation that characterized glioblastoma development. Here, we review the role of microenvironment in development of glioblastoma in the dog species as an animal model for human disease for a better understanding of underlined mechanism(s) and possible target therapy for the benefit of both species. A comparative approach to the study of canine glioblastoma provides an excellent animal model for human glioblastoma pathogenesis and development of novel therapies in both species.