G
George W. J. Fleet
Researcher at University of Oxford
Publications - 626
Citations - 15977
George W. J. Fleet is an academic researcher from University of Oxford. The author has contributed to research in topics: Ring (chemistry) & Isopropyl. The author has an hindex of 60, co-authored 615 publications receiving 15358 citations. Previous affiliations of George W. J. Fleet include G. D. Searle & Company & University of Cambridge.
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Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application
TL;DR: The structural basis for the specificity of inhibition of alkaloidal sugar mimics and their current and potential application to biomedical problems will be reviewed.
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Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.
TL;DR: Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms, and only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.
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Amino-sugar glycosidase inhibitors: versatile tools for glycobiologists
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Inhibition of HIV replication by amino-sugar derivatives.
George W. J. Fleet,Abraham Karpas,Raymond A. Dwek,Linda E. Fellows,A.S. Tyms,Sigthor Petursson,Sung K. Namgoong,Nigel Ramsden,P.W. Smith,Jong Chan Son,Francis Xavier Wilson,Witty David R,Gary S. Jacob,Gary S. Jacob,Thomas W. Rademacher +14 more
TL;DR: The relative efficacy of a spectrum of amino‐sugar derivatives as inhibition of HIV cytopathicity is reported, and several α‐glucosidase inhibitors and α‐fucosinase inhibitors were found to be active at concentrations which were non‐cytotoxic.
Journal ArticleDOI
Aminosugar derivatives as potential anti-human immunodeficiency virus agents
Abraham Karpas,George W. J. Fleet,Raymond A. Dwek,Sigthor Petursson,Sung K. Namgoong,Nigel Ramsden,Gary S. Jacob,Thomas W. Rademacher +7 more
TL;DR: A method to score in parallel both the degree of antiviral activity and the effect on cell division of aminosugar derivatives suggests that replication is associated with cytolysis, which has important implications in the chemotherapy of AIDS.