Journal ArticleDOI
Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.
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Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms, and only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.About:
This article is published in Phytochemistry.The article was published on 2001-02-01. It has received 643 citations till now.read more
Citations
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α- and β-Glucosidase inhibitors: chemical structure and biological activity
TL;DR: This review is aimed at highlighting the main chemical classes of glucosidase inhibitors, as well as their biological activities toward α- and β-glucosidases, but it is not intended to be an exhaustive review on the subject.
Journal ArticleDOI
Potential of Cameroonian plants and derived products against microbial infections: a review.
TL;DR: Many plant species are used in traditional medicine in Cameroon to treat infectious diseases, and several interesting openings have originated for further inquiry following IN VITRO antimicrobial activity evaluation.
Journal ArticleDOI
Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step
TL;DR: The most recent applications of the ring-closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids are described in this paper.
Journal ArticleDOI
Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans
Toshiyuki Kimura,Kiyotaka Nakagawa,Hiroyuki Kubota,Yoshihiro Kojima,Yuko Goto,Kenji Yamagishi,Shigeru Oita,Shinichi Oikawa,Teruo Miyazawa +8 more
TL;DR: It is suggested that the newly developed DNJ-enriched powder can be used as a dietary supplement for preventing diabetes mellitus.
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Iminosugars past, present and future: medicines for tomorrow.
TL;DR: This review focuses on the breadth of opportunities provided by second-generation leads from iminosugars (Seglins™), which can address a variety of established targets that have previously proved refractory to other compound classes.
References
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BookDOI
Alkaloids : chemical and biological perspectives
TL;DR: In this paper, the total synthesis of amaryllidaceae alkaloids has been studied using radical cyclization reactions in total syntheses of naturally occurring indole alkaloid.
Journal Article
Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives.
TL;DR: In contrast to phosphorylation, which directly modulates pro tein function, glycosylation affects the conformation, localization, and organization of functional and structural proteins; thus, gly cosylation determines the turnover and organizational frame work of proteins within cytoplasm, membranes, and the pericellular matrix.
Journal ArticleDOI
Dose: A Critical Factor in Cancer Chemotherapy
Emil Frei,George P. Canellos +1 more
TL;DR: When high doses or concentrations of antitumor therapy can be achieved, such as in the marrow transplant situation and in isolation perfusion or regional infusion studies, there is in general clear evidence that a substantial increase in response rate occurs.
Journal ArticleDOI
Accelerated transport and maturation of lysosomal alpha-galactosidase A in Fabry lymphoblasts by an enzyme inhibitor.
TL;DR: 1–deoxy–galactonojirimycin (DGJ), a potent competitive inhibitor of α–Gal A, effectively enhanced α-Gal A activity in Fabry lymphoblasts, when administrated at concentrations lower than that usually required for intracellular inhibition of the enzyme.
Book ChapterDOI
Glycoside Hydrolases: Mechanistic Information from Studies with Reversible and Irreversible Inhibitors
TL;DR: The results of the studies that permit some generalizations on the catalytic mechanism of glycoside hydrolases from widely differing sources and with different sugar and aglycon specificities and that have become available over the past 15 years are discussed.