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Showing papers by "George W. Nelson published in 2019"

Journal Article•DOI•
Relationship between human leukocyte antigen alleles and risk of Kaposi’s sarcoma in Cameroon

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Elena M. Cornejo Castro1, Brian J. Morrison1, Vickie Marshall1, Nazzarena Labo1, Wendell Miley1, Nathan Clements1, George W. Nelson, Paul Ndom, Kristen Stolka2, Jennifer Hemingway-Foday2, Mahamat Abassora, Xiaojiang Gao, Jennifer S. Smith3, Mary Carrington4, Denise Whitby1 •
Leidos1, Research Triangle Park2, University of California, San Diego3, Ragon Institute of MGH, MIT and Harvard4
20 May 2019-Genes and Immunity
TL;DR: This study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis and identifies the HLA-B and -DQA1 loci as possible risk factors for endemic KS.
Abstract: Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi’s Sarcoma (KS). However, there is little concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case–control study, we performed high-resolution HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of HLA-B*14:01 were at a significantly higher risk of AIDS-KS (p = 0.033). For HIV-negative patients, a gene-wise comparison of allele frequencies identified the HLA-B (p = 0.008) and -DQA1 (p = 0.002) loci as possible risk factors for endemic KS. Our study provides additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of these associations.

10 citations