George X. Sedikides

TL;DR: The response of a subset of immune cells (CD4+ T cells) to HCMV proteins in healthy donors of all ages is investigated, and it is demonstrated that the functionality of CD4- T cells is maintained.

TL;DR: This study suggests in healthy aged donors that HCMV-specific changes in the T cell compartment were not affected by age and were effective, as viremia was a very rare event.

TL;DR: There is only limited evidence supportive of “memory inflation” occurring in humans and that future studies need to investigate immune cells from a broad range of human tissue sites to fully understand the nature of HCMV T cell memory responses to lytic and latent infection.

TL;DR: It is validated that major histocompatibility complex (MHC) class II and two pyrin and HIN domain (PYHIN) proteins, myeloid cell nuclear differentiation antigen (MNDA) and IFI16, are downregulated during experimental latency in primary human CD14+ monocytes, and it is found that IFI 16 is targeted rapidly during the establishment of latency in a US28-dependent manner but only in undifferentiated myeloids cells, a

TL;DR: An unbiased proteomic screen is used to assess changes in host proteins induced by US28, revealing that interferon-inducible genes are downregulated by US 28, and it is validated that MHC Class II and two PYHIN proteins, MNDA and IFI16, are down regulated during experimental latency in primary human CD14+ monocytes.