G
Georgia Dalagiorgou
Researcher at Pasteur Institute
Publications - 7
Citations - 153
Georgia Dalagiorgou is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Chromatin immunoprecipitation & Hepatitis C virus. The author has an hindex of 7, co-authored 7 publications receiving 141 citations. Previous affiliations of Georgia Dalagiorgou include Democritus University of Thrace.
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Journal ArticleDOI
High levels of HCV core+ 1 antibodies in HCV patients with hepatocellular carcinoma
Georgia Dalagiorgou,Georgia Dalagiorgou,Niki Vassilaki,Pelagia Foka,Anissa Boumlic,Anissa Boumlic,Athanassios Kakkanas,Emmanouil Kochlios,S. Khalili,E. Aslanoglou,Stavroula Veletza,Georges Orfanoudakis,Dimitrios Vassilopoulos,Stephanos J. Hadziyannis,John Koskinas,Penelope Mavromara +15 more
TL;DR: The high occurrence of anti-core+1 antibodies in the serum of HCC patients suggests a role for the ARFP/F/ core+1 protein in the pathogenesis of H CC.
Journal ArticleDOI
Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity
Pelagia Foka,Eirini Karamichali,Georgia Dalagiorgou,Elisavet Serti,P.P. Doumba,George Pissas,Athanassios Kakkanas,Dorothea Kazazi,Emmanouil Kochlios,Maria Gaitanou,John Koskinas,Urania Georgopoulou,Penelope Mavromara +12 more
TL;DR: In this article, the authors investigated the modulation of ANGPTL-3 by HCV core and identified the molecular mechanisms involved in the down-regulation of HDL-3 gene expression.
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Novel tumour-specific promoters for transcriptional targeting of hepatocellular carcinoma by herpes simplex virus vectors.
Pelagia Foka,Aldo Pourchet,Ruben Hernandez-Alcoceba,P.P. Doumba,George Pissas,Vlassis Kouvatsis,Georgia Dalagiorgou,Dorothea Kazazi,Peggy Marconi,Mariagiovanna Foschini,Roberto Manservigi,Manousos M. Konstadoulakis,John Koskinas,Alberto L. Epstein,Penelope Mavromara +14 more
TL;DR: The present study aimed to identify novel HCC‐specific promoters that could efficiently direct transgene expression to HCC cells and maintain their activity during active viral replication.
Journal ArticleDOI
ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains.
Haralabia Boleti,Despina Smirlis,Georgia Dalagiorgou,Eliane F. Meurs,Savvas Christoforidis,Penelope Mavromara +5 more
TL;DR: This study characterized NS4B elements involved in the process of targeting, association and retention in the ER membrane and found the C-terminal 70peptidic sequence can associate with membranes positive for ER markers in the absence of any predicted TMs.
Journal ArticleDOI
Internal translation initiation stimulates expression of the ARF/core+1 open reading frame of HCV genotype 1b.
Anissa Boumlic,Niki Vassilaki,Georgia Dalagiorgou,Emmanouil Kochlios,Athanassios Kakkanas,Urania Georgopoulou,Panagiotis Markoulatos,Georges Orfanoudakis,Penelope Mavromara +8 more
TL;DR: Evidence is provided for the synthesis of Core+1 proteins by internal translation initiation in transiently transfected mammalian cells using nuclear or cytoplasmic expression systems and the expression of Core-1 ORF from HCV-1b clinical isolates and the preservation of translation initiation mechanism that stimulates its expression encourage investigating the role of these proteins in HCV pathogenesis.