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Georgina A Holloway
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 7
Citations - 2925
Georgina A Holloway is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Tropane & Trypanosoma cruzi. The author has an hindex of 5, co-authored 7 publications receiving 2368 citations.
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Journal ArticleDOI
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
TL;DR: A number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochemical high throughput screens are described.
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Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity
Georgina A Holloway,William N. Charman,Alan H. Fairlamb,Reto Brun,Marcel Kaiser,Edmund Kostewicz,Patrizia M Novello,John P Parisot,John L. Richardson,Ian P. Street,Keith G. Watson,Jonathan B. Baell +11 more
TL;DR: This paper explores the process of identifying, investigating, and evaluating a series of hits from a high-throughput screening campaign that led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation.
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Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.
Georgina A Holloway,Jonathan B. Baell,Alan H. Fairlamb,Patrizia M Novello,John P Parisot,John L. Richardson,Keith G. Watson,Ian P. Street +7 more
TL;DR: These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.
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Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity
Theola Louie,Theola Louie,C. Dean Goodman,Georgina A Holloway,Geoffrey I. McFadden,Vanessa Mollard,Keith G. Watson +6 more
TL;DR: Several commercial herbicides, all known to be inhibitors of maize acetyl-CoA carboxylase, were also tested for antimalarial activity, but were essentially inactive with the exception of butroxydim which gave an IC(50) of 10 microM.
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Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides.
Christopher D. Goodman,Vanessa Mollard,Theola Louie,Georgina A Holloway,Keith G. Watson,Geoffrey I. McFadden +5 more
TL;DR: It is suggested that herbicides that inhibit the plastid acetyl Coenzyme A (Co-A) carboxylase of plants also kill Plasmodium falciparum in vitro, but their mode of action remains undefined, as this pathway is not essential in blood stages of the parasite.