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Patrizia M Novello
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 5
Citations - 123
Patrizia M Novello is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Tropane & Trypanosoma cruzi. The author has an hindex of 4, co-authored 5 publications receiving 113 citations.
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Journal ArticleDOI
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity
Georgina A Holloway,William N. Charman,Alan H. Fairlamb,Reto Brun,Marcel Kaiser,Edmund Kostewicz,Patrizia M Novello,John P Parisot,John L. Richardson,Ian P. Street,Keith G. Watson,Jonathan B. Baell +11 more
TL;DR: This paper explores the process of identifying, investigating, and evaluating a series of hits from a high-throughput screening campaign that led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation.
Journal ArticleDOI
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.
Georgina A Holloway,Jonathan B. Baell,Alan H. Fairlamb,Patrizia M Novello,John P Parisot,John L. Richardson,Keith G. Watson,Ian P. Street +7 more
TL;DR: These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.
Journal ArticleDOI
Therapeutic Effects of a TANK-Binding Kinase 1 Inhibitor in Germinal Center-Driven Collagen-Induced Arthritis.
Cynthia Louis,Devi Ngo,Damian B D'Silva,Jacinta Hansen,Louisa J. Phillipson,Helene Jousset,Patrizia M Novello,David J. Segal,Kate E. Lawlor,Christopher J. Burns,Ian P. Wicks +10 more
TL;DR: This study undertook this study to assess the therapeutic potential of TBK‐1 inhibition using the small‐molecule inhibitor WEHI‐112 in antibody‐dependent models of inflammatory arthritis.
Journal ArticleDOI
Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.
Georgina A Holloway,John P Parisot,Patrizia M Novello,Keith G. Watson,Tanya Armstrong,R.C.A. Thompson,Ian P. Street,Jonathan B. Baell +7 more
TL;DR: A trifluoromethyl-containing analogue with an EC(50) against T. cruzi of 30 nM and a cytotoxicity selectivity index of over 1000 relative to rat skeletal myoblast L-6 cells is discovered.
Journal ArticleDOI
Discovery of Novel and Potent Benzhydryl‐Tropane Trypanocides Highly Selective for Trypanosoma cruzi.
Georgina A Holloway,John P Parisot,Patrizia M Novello,Keith G. Watson,Tanya Armstrong,R.C.A. Thompson,Ian P. Street,Jonathan B. Baell +7 more
TL;DR: A trifluoromethyl-containing analogue with an EC50 of 30 nM and a cytotoxicity selectivity index of over 1000 relative to rat skeletal myoblast L-6 cells was found in this article.