Georgina A Holloway

TL;DR: A number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochemical high throughput screens are described.

TL;DR: This paper explores the process of identifying, investigating, and evaluating a series of hits from a high-throughput screening campaign that led to the identification of nine novel chemical classes of trypanothione reductase (TR) inhibitors worthy of further investigation.

TL;DR: These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.

TL;DR: Several commercial herbicides, all known to be inhibitors of maize acetyl-CoA carboxylase, were also tested for antimalarial activity, but were essentially inactive with the exception of butroxydim which gave an IC(50) of 10 microM.

TL;DR: It is suggested that herbicides that inhibit the plastid acetyl Coenzyme A (Co-A) carboxylase of plants also kill Plasmodium falciparum in vitro, but their mode of action remains undefined, as this pathway is not essential in blood stages of the parasite.