抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Sentiment analysis and opinion mining is the field of study that analyzes people's opinions, sentiments, evaluations, attitudes, and emotions from written language. It is one of the most active research areas in natural language processing and is also widely studied in data mining, Web mining, and text mining. In fact, this research has spread outside of computer science to the management sciences and social sciences due to its importance to business and society as a whole. The growing importance of sentiment analysis coincides with the growth of social media such as reviews, forum discussions, blogs, micro-blogs, Twitter, and social networks. For the first time in human history, we now have a huge volume of opinionated data recorded in digital form for analysis. Sentiment analysis systems are being applied in almost every business and social domain because opinions are central to almost all human activities and are key influencers of our behaviors. Our beliefs and perceptions of reality, and the choices we make, are largely conditioned on how others see and evaluate the world. For this reason, when we need to make a decision we often seek out the opinions of others. This is true not only for individuals but also for organizations. This book is a comprehensive introductory and survey text. It covers all important topics and the latest developments in the field with over 400 references. It is suitable for students, researchers and practitioners who are interested in social media analysis in general and sentiment analysis in particular. Lecturers can readily use it in class for courses on natural language processing, social media analysis, text mining, and data mining. Lecture slides are also available online.

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Sentiment Analysis and Opinion Mining

Unsupervised vector-based approaches to semantics can model rich lexical meanings, but they largely fail to capture sentiment information that is central to many word meanings and important for a wide range of NLP tasks. We present a model that uses a mix of unsupervised and supervised techniques to learn word vectors capturing semantic term--document information as well as rich sentiment content. The proposed model can leverage both continuous and multi-dimensional sentiment information as well as non-sentiment annotations. We instantiate the model to utilize the document-level sentiment polarity annotations present in many online documents (e.g. star ratings). We evaluate the model using small, widely used sentiment and subjectivity corpora and find it out-performs several previously introduced methods for sentiment classification. We also introduce a large dataset of movie reviews to serve as a more robust benchmark for work in this area.

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Learning Word Vectors for Sentiment Analysis

The measurement of meaning

We present a lexicon-based approach to extracting sentiment from text. The Semantic Orientation CALculator (SO-CAL) uses dictionaries of words annotated with their semantic orientation (polarity and strength), and incorporates intensification and negation. SO-CAL is applied to the polarity classification task, the process of assigning a positive or negative label to a text that captures the text's opinion towards its main subject matter. We show that SO-CAL's performance is consistent across domains and in completely unseen data. Additionally, we describe the process of dictionary creation, and our use of Mechanical Turk to check dictionaries for consistency and reliability.

Lexicon-based methods for sentiment analysis

A huge number of informal messages are posted every day in social network sites, blogs, and discussion forums. Emotions seem to be frequently important in these texts for expressing friendship, showing social support or as part of online arguments. Algorithms to identify sentiment and sentiment strength are needed to help understand the role of emotion in this informal communication and also to identify inappropriate or anomalous affective utterances, potentially associated with threatening behavior to the self or others. Nevertheless, existing sentiment detection algorithms tend to be commercially oriented, designed to identify opinions about products rather than user behaviors. This article partly fills this gap with a new algorithm, SentiStrength, to extract sentiment strength from informal English text, using new methods to exploit the de facto grammars and spelling styles of cyberspace. Applied to MySpace comments and with a lookup table of term sentiment strengths optimized by machine learning, SentiStrength is able to predict positive emotion with 60.6p accuracy and negative emotion with 72.8p accuracy, both based upon strength scales of 1–5. The former, but not the latter, is better than baseline and a wide range of general machine learning approaches. © 2010 Wiley Periodicals, Inc.

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Sentiment in short strength detection informal text

Sentiment analysis is concerned with the automatic extraction of sentiment-related information from text. Although most sentiment analysis addresses commercial tasks, such as extracting opinions from product reviews, there is increasing interest in the affective dimension of the social web, and Twitter in particular. Most sentiment analysis algorithms are not ideally suited to this task because they exploit indirect indicators of sentiment that can reflect genre or topic instead. Hence, such algorithms used to process social web texts can identify spurious sentiment patterns caused by topics rather than affective phenomena. This article assesses an improved version of the algorithm SentiStrength for sentiment strength detection across the social web that primarily uses direct indications of sentiment. The results from six diverse social web data sets (MySpace, Twitter, YouTube, Digg, RunnersWorld, BBCForums) indicate that SentiStrength 2 is successful in the sense of performing better than a baseline approach for all data sets in both supervised and unsupervised cases. SentiStrength is not always better than machine-learning approaches that exploit indirect indicators of sentiment, however, and is particularly weaker for positive sentiment in news-related discussions. Overall, the results suggest that, even unsupervised, SentiStrength is robust enough to be applied to a wide variety of different social web contexts.

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Sentiment strength detection for the social web

The microblogging site Twitter generates a constant stream of communication, some of which concerns events of general interest. An analysis of Twitter may, therefore, give insights into why particular events resonate with the population. This article reports a study of a month of English Twitter posts, assessing whether popular events are typically associated with increases in sentiment strength, as seems intuitively likely. Using the top 30 events, determined by a measure of relative increase in (general) term usage, the results give strong evidence that popular events are normally associated with increases in negative sentiment strength and some evidence that peaks of interest in events have stronger positive sentiment than the time before the peak. It seems that many positive events, such as the Oscars, are capable of generating increased negative sentiment in reaction to them. Nevertheless, the surprisingly small average change in sentiment associated with popular events (typically 1% and only 6% for Tiger Woods' confessions) is consistent with events affording posters opportunities to satisfy pre-existing personal goals more often than eliciting instinctive reactions. © 2011 Wiley Periodicals, Inc.

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Sentiment in Twitter events

Most sentiment analysis approaches use as baseline a support vector machines (SVM) classifier with binary unigram weights. In this paper, we explore whether more sophisticated feature weighting schemes from Information Retrieval can enhance classification accuracy. We show that variants of the classic tf.idf scheme adapted to sentiment analysis provide significant increases in accuracy, especially when using a sublinear function for term frequency weights and document frequency smoothing. The techniques are tested on a wide selection of data sets and produce the best accuracy to our knowledge.

A Study of Information Retrieval Weighting Schemes for Sentiment Analysis

Background 
E-communities, social groups interacting online, have recently become an object of interdisciplinary research. As with face-to-face meetings, Internet exchanges may not only include factual information but also emotional information – how participants feel about the subject discussed or other group members. Emotions in turn are known to be important in affecting interaction partners in offline communication in many ways. Could emotions in Internet exchanges affect others and systematically influence quantitative and qualitative aspects of the trajectory of e-communities? The development of automatic sentiment analysis has made large scale emotion detection and analysis possible using text messages collected from the web. However, it is not clear if emotions in e-communities primarily derive from individual group members' personalities or if they result from intra-group interactions, and whether they influence group activities.


Methodology/Principal Findings 
Here, for the first time, we show the collective character of affective phenomena on a large scale as observed in four million posts downloaded from Blogs, Digg and BBC forums. To test whether the emotions of a community member may influence the emotions of others, posts were grouped into clusters of messages with similar emotional valences. The frequency of long clusters was much higher than it would be if emotions occurred at random. Distributions for cluster lengths can be explained by preferential processes because conditional probabilities for consecutive messages grow as a power law with cluster length. For BBC forum threads, average discussion lengths were higher for larger values of absolute average emotional valence in the first ten comments and the average amount of emotion in messages fell during discussions.


Conclusions/Significance 
Overall, our results prove that collective emotional states can be created and modulated via Internet communication and that emotional expressiveness is the fuel that sustains some e-communities.

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Georgios Paltoglou

Papers

Sentiment in short strength detection informal text

Sentiment strength detection for the social web

Sentiment in Twitter events

A Study of Information Retrieval Weighting Schemes for Sentiment Analysis

Collective emotions online and their influence on community life.