G
Gerald F. Sigler
Researcher at Hoffmann-La Roche
Publications - 24
Citations - 350
Gerald F. Sigler is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Analyte & Uncompetitive inhibitor. The author has an hindex of 8, co-authored 24 publications receiving 350 citations. Previous affiliations of Gerald F. Sigler include Roche Diagnostics.
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Patent
Osmium-containing redox mediator
Zhi David Deng,Gerald F. Sigler,Nigel A. Surridge,Christopher D. Wilsey,Robert J. Mcenroe,Walter Jernigan,Rebecca W. Muddiman +6 more
TL;DR: A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors is presented in this article, which are particularly useful as a component of a reagent for measuring analytes from a biological fluid, such as blood.
Patent
Reagent including an osmium-containing redox mediator
Zhi David Deng,Gerald F. Sigler,Nigel A. Surridge,Christopher D. Wilsey,Robert J. Mcenroe,Walter Jernigan,Rebecca W. Muddiman +6 more
TL;DR: A new group of Os(II) and Os(III) compounds were proposed in this paper, which are useful as redox mediators in electrochemical biosensors, where they have low oxidation potential, fast reaction kinetics between the electroactive center of an enzyme and the compound, slow oxidation of osmium by oxygen, and excellent solubility in aqueous medium.
Patent
Enzyme inhibition immunoassay
Mitali Ghoshal,Gerald F. Sigler,Raymond A. Hui,Ronald Charles Hawley,Eva Hoess,Erasmus J. Huber,Patterson John W,Salvatore J. Salamone,Allan R. Dorn +8 more
TL;DR: In this article, an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay for the measurement of an analyte in biological samples, which can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.
Patent
Tissue reactive adhesive compositions
TL;DR: In this paper, a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups is presented.
Patent
Immunoassay for HIV protease inhibitors
TL;DR: In this article, a non-isotopic immunoassay for an HIV protease inhibitor was proposed, in which a sample containing the inhibitor was incubated with a receptor specific for the inhibitor or for a metabolite of said inhibitor and further with a conjugate comprising an analog of the inhibitor and a nonsotopic signal generating moiety.