G
Gerald Gimpl
Researcher at Max Planck Society
Publications - 15
Citations - 2291
Gerald Gimpl is an academic researcher from Max Planck Society. The author has contributed to research in topics: Receptor & Oxytocin receptor. The author has an hindex of 13, co-authored 15 publications receiving 2194 citations.
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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
TL;DR: It is demonstrated that cholesterol reduction promotes the nonamyloidogenic α- secretase pathway and the formation of neuroprotective α-secretase cleaved soluble APP by several mechanisms and suggest approaches to prevention of or therapy for Alzheimer's disease.
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Alteration of the Myometrial Plasma Membrane Cholesterol Content with .beta.-Cyclodextrin Modulates the Binding Affinity of the Oxytocin Receptor
TL;DR: Binding experiments showed that, with the removal of cholesterol from the membrane, the dissociation constant for [3H]oxytocin is enhanced 87-fold, therefore shifting the oxytocin receptor from high to low affinity.
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Cholesterol as modulator of receptor function.
TL;DR: The results suggest that cholesterol can modulate receptor function by two distinct mechanisms, by changes of the membrane fluidity, and/or by a highly specific molecular interaction.
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Expression of the human oxytocin receptor in baculovirus-infected insect cells: high-affinity binding is induced by a cholesterol-cyclodextrin complex.
TL;DR: The high-affinity binding of the oxytocin receptor increased in parallel with the cholesterol levels present in the corresponding plasma membranes, which is approximately 20-fold lower than normally found in plasma membranes of higher eukaryotic cells.
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Direct identification of an extracellular agonist binding site in the renal V2 vasopressin receptor.
TL;DR: The results indicate that this extracellular domain is involved in peptide agonist binding of the V2 receptor.