Showing papers by "Geraldine S. Pinkus published in 1978"

Lymphocyte subpopulations of lymph nodes and spleens in Hodgkin's disease.

Abstract: Lymphocyte subpopulations have been defined for twenty-five involved lymph nodes, ten involved spleens and twenty-five uninvolved spleens of patients with Hodgkin's disease. A predominance of T lymphocytes was observed in involved lymph nodes (77 ± 3% se) and also in involved and uninvolved spleens, with splenic tumor nodules demonstrating the highest T cell values for splenic tissue (75 ± 3% se). The T cell content of involved nodes, however, did not differ significantly from that of a group of hyperplastic nodes. The percentages of T lymphocytes in splenic tumor nodules (75 ± 3% se) and in uninvolved spleens (68 ± 2% se) of patients with Hodgkin's disease were greater (p < 0.05) than those observed for the group of control spleens with traumatic rupture (54 ± 5% se). Histologically uninvolved spleens of patients with Hodgkin's disease demonstrated a higher B cell content (22 ± 2% se) than splenic tumor nodules (13 ± 2% se). The percentage of B lymphocytes observed in spleens with traumatic rupture (47% ± 6% se) was significantly greater than those observed for involved and uninvolved spleens of patients with Hodgkin's disease and those found in spleens of patients with various nonlymphoproliferative disorders. An unusual finding in these studies was the identification of IgMEA rosette forming lymphocytes which were significantly increased (p < 0.01) in nodes infiltrated by Hodgkin's disease (9.3 ± 1.6% se) as compared with a group of hyperplastic nodes (1.6 ± 0.4% se), and in splenic tumor nodules (3.7 ± 0.8% se) as compared with spleens with traumatic rupture (0.4 ± 0.3% se).