G
Gerard A. Lutty
Researcher at Johns Hopkins University School of Medicine
Publications - 214
Citations - 13767
Gerard A. Lutty is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 64, co-authored 211 publications receiving 12338 citations. Previous affiliations of Gerard A. Lutty include Johns Hopkins University & University of California, Davis.
Papers
More filters
Journal ArticleDOI
Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
TL;DR: The mutualistic symbiotic relationship within the photoreceptor/RPE/BrMb/CC complex is lost in both forms of AMD, and loss of this functionally integrated relationship results in death and dysfunction of all of the components in the complex.
Journal ArticleDOI
Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues
TL;DR: In this paper, electron paramagnetic resonance measurements with the spin trap 5,5'-dimethyl-1-pyrroline-N-oxide (DMPO) demonstrate that bovine endothelial cells subjected to anoxia and reoxygenation become potent generators of superoxide and hydroxyl free radicals.
Journal ArticleDOI
Relationship between RPE and choriocapillaris in age-related macular degeneration.
TL;DR: The primary insult in GA appears to be at the level of the RPE, and there is an intimate relationship between retinal pigment epithelial atrophy and secondary CC degeneration.
Journal Article
Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.
TL;DR: It is demonstrated that ICAM-1 and P-selectin are constitutively expressed in the normal choroid and are upregulated in the choroidal vasculature in diabetes, but only IC AM-1 was up regulated in the retina of diabetic subjects.
Journal ArticleDOI
Choriocapillaris degeneration and related pathologic changes in human diabetic eyes.
TL;DR: The percentage of choroid with focal CCD in group 1 choroids was more than 4-fold greater than that in nondiabetic Choroids, and the presence of CCD was related to basal laminar deposits and, in some cases, to choroidal neovascularization.