D
David J. Lefer
Researcher at LSU Health Sciences Center New Orleans
Publications - 171
Citations - 19797
David J. Lefer is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Ischemia & Reperfusion injury. The author has an hindex of 61, co-authored 154 publications receiving 18347 citations. Previous affiliations of David J. Lefer include Tulane University & Yeshiva University.
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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
Yasuko Kureishi,Zhengyu Luo,Ichiro Shiojima,Ann Bialik,David Fulton,David J. Lefer,William C. Sessa,Kenneth Walsh +7 more
TL;DR: Simvastatin enhanced phosphorylation of the endogenous Akt substrate endothelial nitric oxide synthase, inhibited apoptosis and accelerated vascular structure formation in vitro in an Akt-dependent manner, and promoted angiogenesis in ischemic limbs of normocholesterolemic rabbits.
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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
John W. Elrod,John W. Calvert,Joanna Morrison,Jeannette E. Doeller,David W. Kraus,Ling Tao,Xiangying Jiao,Rosario Scalia,Levente Kiss,Csaba Szabó,Hideo Kimura,Chi Wing Chow,David J. Lefer +12 more
TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.
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The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.
Orlando F. Bueno,Leon J. De Windt,Kevin M. Tymitz,Sandra A. Witt,Thomas R. Kimball,Raisa Klevitsky,Timothy E. Hewett,Steven P. Jones,David J. Lefer,Chang Fu Peng,Richard N. Kitsis,Jeffery D. Molkentin +11 more
TL;DR: The results of the present study indicate that the MEK1–ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis.
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Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Mark R. Duranski,James J. M. Greer,Andre Dejam,Sathya Jaganmohan,Neil Hogg,Will Langston,Rakesh P. Patel,Shaw-Fang Yet,Xunde Wang,Christopher G. Kevil,Mark T. Gladwin,David J. Lefer +11 more
TL;DR: The results suggest that nitrite is a biological storage reserve of NO subserving a critical function in tissue protection from ischemic injury and an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states.
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Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling
John W. Calvert,Saurabh Jha,Susheel Gundewar,John W. Elrod,Arun Ramachandran,Christopher B. Pattillo,Christopher G. Kevil,David J. Lefer +7 more
TL;DR: Results reveal that the cardioprotective effects of H2S are mediated in large part by a combination of antioxidant and antiapoptotic signaling.