Block copolymer micelles for drug delivery: design, characterization and biological significance

Biodegradable polymeric nanoparticles as drug delivery devices

Block copolymer (BCP) self-assembly has attracted considerable attention for many decades because it can yield ordered structures in a wide range of morphologies, including spheres, cylinders, bicontinuous structures, lamellae, vesicles, and many other complex or hierarchical assemblies. These aggregates provide potential or practical applications in many fields. The present tutorial review introduces the primary principles of BCP self-assembly in bulk and in solution, by describing experiments, theories, accessible morphologies and morphological transitions, factors affecting the morphology, thermodynamics and kinetics, among others. As one specific example at a more advanced level, BCP vesicles (polymersomes) and their potential applications are discussed in some detail.

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Self-assembly of block copolymers

1: Magnetic Particles: Preparation, Properties and Applications: M. Ozaki. 2: Maghemite (gamma-Fe2O3): A Versatile Magnetic Colloidal Material C.J. Serna, M.P. Morales. 3: Dynamics of Adsorption and Oxidation of Organic Molecules on Illuminated Titanium Dioxide Particles Immersed in Water M.A. Blesa, R.J. Candal, S.A. Bilmes. 4: Colloidal Aggregation in Two-Dimensions A. Moncho-Jorda, F. Martinez-Lopez, M.A. Cabrerizo-Vilchez, R. Hidalgo Alvarez, M. Quesada-PMerez. 5: Kinetics of Particle and Protein Adsorption Z. Adamczyk.

Surface and Colloid Science

http://wwwcourses.sens.buffalo.edu/ce435/Riess03.pdf

Micellization of block copolymers

Production of polyethylene oxide films comprises dissolving an ethylene oxide (co)polymer and optionally another water-soluble polymer in aqueous and/or organic solvent containing photoinitiator or crosslinker; evaporating the solvent to form a film with a water content of 10-100 % wt.% of polymer (with rehydration if neeeded); and irradiating the film with UV radiation of wavelength 200-400 nm.

Production of crosslinked polyethylene oxide films useful as biomaterials comprises irradiating a film having a defined water content

High impact polystyrenes (HIPS) and ABS resins (acrylonitrile, butadiene, styrene) are two phase systems combining rigidity and impact strength. HIPS and ABS are generally obtained by polymerization of styrene, or of a styrene-acrylonitrile mixture, in the presence of polybutadiene (PBut). In this reaction, poly (butadiene-g-styrene) graft copolymer, having a PBut backbone and polystyrene grafts (PSg), is formed simultaneously with non grafted polystyrene (PS1). These graft copolymers, acting as oil in oil emulsifiers have an important influence on the morphology and on the mechanical properties of such products (1–3).

Grafting Kinetics in the Case of Rubber Modified Polymers. ABS and HIPS Systems

Étude de la degradation mécanochimique du polybutadiène en solution par agitation ultrarapide

Synthèse et caractérisation de matériaux thermoplastiques biphasiques obtenus à partir de latex de polystyrène réticulé

Block copolymers whose methods of synthesis have been covered in a preceeding article (1) represent one of the fastest growing areas of polymer science, interest stemming principally from their unique properties in a solvated, colloidal or solid state.

Gérard Riess

Papers

Production of crosslinked polyethylene oxide films useful as biomaterials comprises irradiating a film having a defined water content

Grafting Kinetics in the Case of Rubber Modified Polymers. ABS and HIPS Systems

Étude de la degradation mécanochimique du polybutadiène en solution par agitation ultrarapide

Synthèse et caractérisation de matériaux thermoplastiques biphasiques obtenus à partir de latex de polystyrène réticulé

Colloidal Behaviour and Surface Activity of Block Copolymers